Citation: Lin Zhilan, Zhang Junmin, Gao Yuan. A Convenient Method to Prepare Pyrano[2,3-d]pyrimidine Derivatives[J]. Chinese Journal of Organic Chemistry, ;2016, 36(3): 659-663. doi: 10.6023/cjoc201509037 shu

A Convenient Method to Prepare Pyrano[2,3-d]pyrimidine Derivatives

1.
College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060

Corresponding author: Gao Yuan,
Received Date: 28 September 2015
Available Online: 26 October 2015
Fund Project: 国家自然科学基金(No. 21402124)资助项目. (No. 21402124)

A series of pyrano[2,3-d]pyrimidine derivatives were synthesized by the reaction of 2-amino-3-cyano-4H-pyrans with acetic anhydride. This method has the advantages of short reaction times (10~15 min), simple operation and convenient post-treatment. All products were fully characterized by IR and ¹H NMR spectra. The molecular structures of 4a and 6a were confirmed using single-crystal X-ray analyses.
- pyrano[2,3-d]pyrimidine derivatives,
- 2-amino-3-cyano-4H-pyran derivatives,
- acid catalysis
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