Citation: Cheng Yu, Wang Hui, Addla Dinesh, Zhou Chenghe. Current Researches and Applications of Azole-BasedSupermolecules as Medicinal Agents[J]. Chinese Journal of Organic Chemistry, ;2015, 36(1): 1-42. doi: 10.6023/cjoc201509006 shu

Current Researches and Applications of Azole-BasedSupermolecules as Medicinal Agents

1.
Key Laboratory of Applied Chemistry of Chongqing Municipality, Institute of Bioorganic & Medicinal Chemistry, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715

Corresponding author: Cheng Yu, zhouch@swu.edu.cn
Received Date: 5 September 2015
Revised Date: 4 October 2015

Fund Project: the National Natural Science Foundation of China 21372186the National Natural Science Foundation of China 81450110451 (International (Regional) Cooperation and Exchange Program)the Specialized Research Fund for the Doctoral Program of Higher Education of China SRFDP 20110182110007the Natural Science Foundation of Chongqing City CSTC2012jjB10026the National Natural Science Foundation of China 21172181

Noncovalent bond forces-based supramolecular chemistry grows quite rapidly and has been revealed to have extensively potential applications and huge development values in chemistry, physics, materials and information science, medicine and so on. Azole compounds such as imidazoles, thiazoles, oxazoles, pyrazoles, triazoles, tetrazoles and carbazoles containing special nitrogen aromatic heterocyclic structure, can exert non-covalent forces to form supramolecular complexes with inorganic and/or organic compounds and exhibit broad biological activity. In recent years, heterocyclic azole-based supramolecular complexes have been expeditiously expanding in the field of medicine, and have become a quite hot topic. Combined with our work and referring to other literature in recent 5 years, this paper systematically reviews the researches and applications of azole-based supermolecules as medicinal agents including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, anti-inflammatory drugs and other ones. Finally, the perspectives of the future development of azole-based supermolecules as medicinal agents are also presented.
- supermolecule,
- azole,
- anticancer,
- antibacterial,
- antifungal,
- antidiabetic,
- antihypertensive,
- anti-inflammatory
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