Citation: Dai Hong, Li Hong, Jin Zhichao, Liu Wenyong, Xiao Yao, He Haibing, Wang Qingmin, Shi Yujun. Synthesis and Bioactivity of Novel 1-Methyl-3-trifluoromethyl-5-subsituent-1H-pyrazole-4-carbaldehyde-O-(4-trifluoromethylbenzoyl)oximes[J]. Chinese Journal of Organic Chemistry, ;2015, 36(1): 185-190. doi: 10.6023/cjoc201508028 shu

Synthesis and Bioactivity of Novel 1-Methyl-3-trifluoromethyl-5-subsituent-1H-pyrazole-4-carbaldehyde-O-(4-trifluoromethylbenzoyl)oximes

Dai Hong ^a,b ,
Li Hong ^c ,
Jin Zhichao ^a ,
Liu Wenyong ^a ,
Xiao Yao ^a ,
He Haibing ^a,*,, ,
Wang Qingmin ^b ,
Shi Yujun ^a,*,,

a.
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
b.
State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071
c.
Nantong Fengtian Chemical Industry Co. Ltd, Nantong 226005

Corresponding author: He Haibing, hhb3812@163.com Shi Yujun, yjshi2015@163.com
Received Date: 29 August 2015
Revised Date: 8 October 2015

Fund Project: the Science and Technology Project Fund of Nantong City CP12013002the National Natural Science Foundation of China 21372135the Science and Technology Project Fund of Nantong City AS2013004the Natural Science Foundation of Jiangsu Province BK20140425the National Natural Science Foundation of China 21202089the Science and Technology Project Fund of Nantong City AS2014011

Figures(1)

In order to find novel pesticide from pyrazole compounds, a series of new pyrazole derivatives carrying trifluoromethyl benzoyl oxime ester moiety were prepared. The structures of all the title compounds were determined by ¹H NMR, ¹³C NMR, MS and elemental analysis. Preliminary bioassay displayed that most of the target compounds showed certain insecticidal activities at the concentration of 500 μg/mL. When the concentration was reduced to 200 μg/mL, compounds 5b, 5c, 5d, 5i, 5l and 5n werestill active against Aphis craccivora with inhibitory values of 90%, 90%, 80%, 80%, 80% and 80%, respectively.
- trifluoromethyl benzoyl,
- pyrazole,
- synthesis,
- biological activity
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