Citation: Hou Shuhua, Qu Zhongguo, Zhong Keli, Bian Yanjiang, Tang Lijun. Recent Advances in Nicotinamide Adenine Dinucluotide (NAD⁺) Analogs Synthesis and Their Interactions with NAD⁺-Dependent Enzymes[J]. Chinese Journal of Organic Chemistry, ;2016, 36(2): 297-305. doi: 10.6023/cjoc201508010 shu

Recent Advances in Nicotinamide Adenine Dinucluotide (NAD⁺) Analogs Synthesis and Their Interactions with NAD⁺-Dependent Enzymes

1.
Liaoning Key Laboratory for the Synthesis and Application of Functional Compounds, Department of Chemistry, Bohai University, Jinzhou 121013

Corresponding author: Hou Shuhua,
Received Date: 9 August 2015
Available Online: 15 September 2015

Interactions between nicotiamide adenine dinucleotide (NAD⁺) and NAD⁺-dependent enzyme play a crucial role in cellular redox state, energy metabolism, catabolism, anabolism and signal transduction. The rules of interaction between NAD⁺and NAD⁺-dependent enzyme have attracted increasing attention due to so many cellular processes are connected to NAD⁺. This review highlights some recent progresses in the fields of NAD⁺analogs synthesis and interactions with NAD⁺- dependent enzyme including the synthesis of NAD⁺analogs and its interactions with wild NAD⁺-dependent enzyme, interactions between NAD⁺and mutant enzymes, interactions between NAD⁺analogs and mutant enzymes.
- NAD⁺,
- NAD⁺analog,
- NAD⁺-dependent enzyme,
- interaction
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Recent Advances in Nicotinamide Adenine Dinucluotide (NAD+) Analogs Synthesis and Their Interactions with NAD+-Dependent Enzymes

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通讯作者: 陈斌, bchen63@163.com

Recent Advances in Nicotinamide Adenine Dinucluotide (NAD⁺) Analogs Synthesis and Their Interactions with NAD⁺-Dependent Enzymes