Citation: Zhang Di, Xie Xiong, Feng Jinsheng, Wen Hongliang. Study on the Synthesis of (+)-Oxocamphor[J]. Chinese Journal of Organic Chemistry, ;2015, 36(1): 202-206. doi: 10.6023/cjoc201506023 shu

Study on the Synthesis of (+)-Oxocamphor

1.
School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081

Corresponding author: Wen Hongliang, wen.hongliang816@gmail.com; analchemie@bit.edu.cn
Received Date: 17 June 2015
Revised Date: 30 August 2015

Figures(6)

(+)-Oxocamphor is a metabolite of (+)-camphor in vivo, which is used to treat heart failure in clinic. However the present synthetic method has problems of long reaction time, serious pollution and low yield. In this paper we report an efficient synthesis of (+)-oxocamphor was reported via bromination, reduction, esterification, hydrolysis and oxidation using (+)-camphor as starting material. All the intermediates and (+)-oxocamphor were confirmed by ¹H NMR, IR and GC-MS. The absolute configuration of 3, 9-dibromocamphor was also ascertained by X-ray diffraction analysis. The overall yield of these 6-step procedures was about 10%.
- (+)-oxocamphor,
- synthesis,
- single crystal
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沈阳化工大学材料科学与工程学院沈阳 110142