Citation: Li Pengcheng, Weng Guodong, Zhang Yongdong, Zhang Xingxian. A Highly Efficient Paal-Knorr Synthesis of Chiral Pyrrole Derivatives Catalyzed by MgI₂[J]. Chinese Journal of Organic Chemistry, ;2016, 36(2): 364-369. doi: 10.6023/cjoc201505041 shu

A Highly Efficient Paal-Knorr Synthesis of Chiral Pyrrole Derivatives Catalyzed by MgI₂

1.
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310032

Corresponding author: Zhang Xingxian,
Received Date: 25 May 2015
Available Online: 17 August 2015
Fund Project: 国家自然科学基金(Nos. 21372203,21272076) (Nos. 21372203,21272076)国家大学生创新创业计划(No. 201310337007) (No. 201310337007)浙江省新苗人才计划(No. 2014R403021)资助项目 (No. 2014R403021)

A novel methodology has been developed for the synthesis of N-substituted mono-pyrrole and bis-pyrrole derivatives with a chiral substituent at the nitrogen atom by MgI₂-catalyzed Paal-Knorr condensation using esters of amino acids as the source of chirality. This method has some advantages such as mild reaction conditions, simple procedure, good yields, high stereoselectivity and environmental friendliness.
- 2,5-hexadione,
- chiral amino acid esters,
- magnesium iodide,
- Paal-Knorr condensation,
- chiral pyrrole derivatives
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

A Highly Efficient Paal-Knorr Synthesis of Chiral Pyrrole Derivatives Catalyzed by MgI2

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通讯作者: 陈斌, bchen63@163.com

A Highly Efficient Paal-Knorr Synthesis of Chiral Pyrrole Derivatives Catalyzed by MgI₂