Citation: Xinshuo Zhao, Haiyan Qiu, Yi Shao, Panjie Wang, Shilong Yu, Hai Li, Yubin Zhou, Zhan Zhou, Lufang Ma, Chaoliang Tan. Silver Nanoparticle-Modified 2D MOF Nanosheets for Photothermally Enhanced Silver Ion Release Antibacterial Treatment[J]. Acta Physico-Chimica Sinica, ;2023, 39(7): 221104. doi: 10.3866/PKU.WHXB202211043 shu

Silver Nanoparticle-Modified 2D MOF Nanosheets for Photothermally Enhanced Silver Ion Release Antibacterial Treatment

Xinshuo Zhao ^{1, 4, †} ,
Haiyan Qiu ^{2, 3, †} ,
Yi Shao ¹ ,
Panjie Wang ¹ ,
Shilong Yu ⁵ ,
Hai Li ⁵ ,
Yubin Zhou ^{2, 3,,} ,
Zhan Zhou ^1,, ,
Lufang Ma ^{1, 4,,} ,
Chaoliang Tan ^{6, 7,,}

1.
College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang 471934, Henan Province, China
2.
The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, Guangdong Province, China
3.
Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs and School of Pharmacy, Guangdong Medical University, Dongguan 523808, Guangdong Province, China
4.
College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454000, Henan Province, China
5.
Institute of Advanced Materials, Key Laboratory of Flexible Electronics, Nanjing Tech University, Nanjing 211816, China
6.
Department of Chemistry and Center of Super-Diamond and Advanced Films (COSDAF), City University of Hong Kong, Kowloon, Hong Kong SAR 999077, China
7.
Shenzhen Research Institute, City University of Hong Kong, Shenzhen 518057, Guangdong Province, China

Corresponding author: Yubin Zhou, zybresearch@126.com Zhan Zhou, zhouzhan@lynu.edu.cn Lufang Ma, mazhuxp@126.com Chaoliang Tan, chaoltan@cityu.edu.hk

^†

Received Date: 23 November 2022
Revised Date: 5 January 2023
Accepted Date: 6 January 2023
Available Online: 16 January 2023
Fund Project: the National Natural Science Foundation of China 52102348the National Natural Science Foundation of China 22171123the National Natural Science Foundation of China 22005259the Science and Technology Innovation Talent Program of University in Henan Province 23HASTIT016the Guangdong Basic and Applied Basic Research Foundation 2019A1515111112the Guangdong Basic and Applied Basic Research Foundation 2021A1515011831the Special Projects in Key Areas for General Colleges and Universities of Guangdong Province 2021ZDZX2061the Start-Up Grant from City University of Hong Kong 9610495

Recently, two-dimensional (2D) metal-organic framework (MOF) nanosheet-based composites have been extensively investigated as promising materials for biomedical applications, including antibacterial applications. This study reports the synthesis of silver nanoparticle (Ag NP)-modified 2D Zr-ferrocene-MOF (MOF-Ag) nanosheets by growing Ag NPs on 2D MOF nanosheets via light irradiation-induced reduction for photothermally enhanced silver ion (Ag⁺) release antibacterial treatment. The MOF nanosheets were synthesized by a hydrothermal method followed by ultrasonic treatment. Subsequently, Ag NPs were grown on the MOF nanosheets to obtain MOF-Ag nanosheets by in situ light irradiation-induced reduction. Various characterization results, including transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and inductively coupled plasma-mass spectrometry (ICP-MS), showed that Ag NPs were successfully loaded onto the surface of the MOF nanosheets. Fourier transform infrared (FTIR) spectroscopy further confirmed the successful modification of the MOF-Ag surface with polyvinylpyrrolidone (PVP). The modification with of PVP not only enhanced the stability of MOF-Ag in solution, but also enhanced its biocompatibility. Under 808 nm near-infrared laser (NIR) irradiation, the MOF nanosheets exhibited good photothermal properties and photothermal conversion efficiency. The temperature increase induced by the photothermal effect accelerates the oxidation of Ag NPs to Ag⁺, and thus MOF-Ag continuously releases silver ions to kill bacteria. It was concluded that PVP-functionalized MOF-Ag (PVP@MOF-Ag) nanosheets have good antibacterial properties using experimental analyses such as bacterial growth curves, relative number of colonies, and morphological changes of bacteria. PVP@MOF-Ag nanosheets not only kills S. aureus but also inhibits E. coli growth more efficiently, exhibiting broad-spectrum bactericidal properties. Additionally, the good photothermal performance of the 2D MOF nanosheets enhanced Ag⁺ release and cell membrane permeability. Ag NPs release Ag⁺ in solution via an oxidation mechanism, and the released Ag⁺ is more likely to enter the bacteria via the cell membrane under light conditions. In bacteria, Ag⁺ induces the generation of endogenous reactive oxygen species to trigger oxidative stress, thus realizing efficient antibacterial performance. Based on the above-mentioned antibacterial mechanism and good in vitro antibacterial properties, the PVP@MOF-Ag nanosheets were used for wound healing in mice. By developing a mouse wound healing model and treating mouse wounds within a week, it was observed that PVP@MOF-Ag nanosheets have a good therapeutic effect and good biosafety during treatment. These results demonstrate that PVP@MOF-Ag nanosheets are an efficient platform for photothermally enhanced Ag⁺ release antibacterial therapy and wound healing.
- 2D MOFs,
- 2D composites,
- Ag⁺ release,
- Photothermal therapy,
- Antibacterial
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沈阳化工大学材料科学与工程学院沈阳 110142