Citation: Shuai Chen, Jianglei Qin, Jianzhong Du. Cross-Linkable Yet Biodegradable Polymer Films[J]. Acta Physico-Chimica Sinica, ;2022, 38(8): 200602. doi: 10.3866/PKU.WHXB202006029 shu

Cross-Linkable Yet Biodegradable Polymer Films

Shuai Chen ^{1, 2} ,
Jianglei Qin ^{3, 4,,} ,
Jianzhong Du ^{1, 2,,}

1.
Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
2.
Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China.
3.
College of Chemistry and Environmental Science, Hebei University, Baoding 071002, Hebei Province, China.
4.
State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China

Corresponding author: Jianglei Qin, qinhbu@iccas.ac.cn Jianzhong Du, jzdu@tongji.edu.cn
Received Date: 11 June 2020
Revised Date: 27 July 2020
Accepted Date: 27 July 2020
Available Online: 31 July 2020
Fund Project: the Natural Science Foundation of Hebei Province, China B2018201140State Key Laboratory of Organic-Inorganic Composites, China oic-202001005the National Science Fund for Distinguished Young Scholars, China 21925505the National Natural Science Foundation of China 21674081

Polymer films are widely used as biomaterials, electronic devices, food packaging materials and gas separation membranes. In practice, cross-linking is an effective method to enhance their stability and increase the strength of these films. However, conventional cross-linked polymer films cannot degrade under mild conditions. Herein, we fabricated two cross-linkable, yet biodegradable, polymer films of ~0.2 mm via solution casting using cinnamate-grafted polycaprolactones, namely: a poly((α-(cinnamoyloxymethyl)-1, 2, 3-triazol) caprolactone) (PCTCL₁₃₃) homopolymer and a poly(caprolactone-stat-CTCL) (P(CL₁₅₆-stat-CTCL₂₈)) copolymer. The successful syntheses of the polymers were confirmed via proton nuclear magnetic resonance (¹H NMR) spectroscopy, size exclusion chromatography (SEC), and Fourier transform infrared (FT-IR) spectroscopy. The PCTCL homopolymer appeared as a transparent film, owing to its side groups that impede its crystallinity; in contrast, the copolymer film appeared translucent, owing to its PCL segments that are easily crystallized. The cinnamate groups facilitated the cross-linking of the polymer films when irradiated by ultraviolet (UV) light; this is indicated by its insoluble character in tetrahydrofuran, which is a good solvent for both polymers. SEC analysis indicated that a fraction of the P(CL₁₅₆-stat-CTCL₂₈) film remained un-cross-linked after irradiation, owing to its crystalline structure. In contrast, UV irradiation caused the PCTCL homopolymer film to become homogeneously cross-linked, which exhibited a cross-linking density of 49% after 2 h as indicated by the ¹H NMR results. Thermogravimetric analysis (TGA) indicated that cross-linking of the PCTCL films caused a minimal change in thermal stability. Both the cross-linked polymer films were able to degrade upon the addition of a modest amount of concentrated hydrochloric acid, as confirmed by SEC and ¹H NMR. However, the degradation rate significantly decreased after cross-linking, thereby indicating its tunable character that can be altered by varying the cross-linking density. In addition, the rate of degradation can be adjusted upon varying the fraction of cross-linked PCTCL groups in the copolymer. In principle, treating the polymer films with sufficient amounts of acid could form degradation products with molecular weights less than 300 g∙mol⁻¹. To further explore the mechanical properties of such materials, we investigated the correlation between the initial concentration used for solution casting and the Young's modulus of the film by employing molecular dynamics simulations. These results indicate that tougher films are prepared when using more concentrated polymer solutions, owing to a higher degree of chain entanglement. In summary, the prepared films with tunable degradability are promising materials for biomedical applications. In principle, this platform could be utilized in hydrogels and coating materials for a broad scope of applications.
- Polymer film,
- Polycaprolactone,
- Photocross-linking,
- Degradability,
- Solution casting
1. [1]
  Cheng, C.; Sun, S. D.; Zhao, C. S. J. Mater. Chem. B 2014, 2, 7649. doi: 10.1039/c4tb01390e doi: 10.1039/c4tb01390e
2. [2]
  Chen, X. Y.; Li, J. S. Mater. Chem. Front. 2020, 4, 750. doi: 10.1039/c9qm00717b doi: 10.1039/c9qm00717b
3. [3]
  Tharanathan, R. N. Trends Food Sci. Technol. 2003, 14, 71. doi: 10.1016/S0924-2244(02)00280-7 doi: 10.1016/S0924-2244(02)00280-7
4. [4]
  Bao, Q. Y.; Braun, S.; Wang, C. F.; Liu, X. J.; Fahlman, M. Adv. Mater. Interfaces 2019, 6, 1800897. doi: 10.1002/admi.201800897 doi: 10.1002/admi.201800897
5. [5]
  Pandey, P.; Chauhan, R. S. Prog. Polym. Sci. 2001, 26, 853. doi: 10.1016/S0079-6700(01)00009-0 doi: 10.1016/S0079-6700(01)00009-0
6. [6]
  Reddy, N.; Reddy, R.; Jiang, Q. R. Trends Biotechnol. 2015, 33, 362. doi: 10.1016/j.tibtech.2015.03.008 doi: 10.1016/j.tibtech.2015.03.008
7. [7]
  Rhim, J. W.; Ng, P. K. W. Crit. Rev. Food Sci. Nutr. 2007, 47, 411. doi: 10.1080/10408390600846366 doi: 10.1080/10408390600846366
8. [8]
  Feng, C.; Huang, X. Y. Acc. Chem. Res. 2018, 51, 2314. doi: 10.1021/acs.accounts.8b00307 doi: 10.1021/acs.accounts.8b00307
9. [9]
  Xu, B. B.; Feng, C.; Hu, J. H.; Shi, P.; Gu, G. X.; Wang, L.; Huang, X. Y. ACS Appl. Mater. Interfaces 2016, 8, 6685. doi: 10.1021/acsami.5b12820 doi: 10.1021/acsami.5b12820
10. [10]
  Xu, B. B.; Liu, Y. J.; Sun, X. W.; Hu, J. H.; Shi, P.; Huang, X. Y. ACS Appl. Mater. Interfaces 2017, 9, 16517. doi: 10.1021/acsami.7b03258 doi: 10.1021/acsami.7b03258
11. [11]
  Sionkowska, A. Prog. Polym. Sci. 2011, 36, 1254. doi: 10.1016/j.progpolymsci.2011.05.003 doi: 10.1016/j.progpolymsci.2011.05.003
12. [12]
  Baroli, B. J. Biomed. Nanotechnol. 2010, 6, 485. doi: 10.1166/jbn.2010.1147 doi: 10.1166/jbn.2010.1147
13. [13]
  Chandra, R.; Rustgi, R. Prog. Polym. Sci. 1998, 23, 1273. doi: 10.1016/S0079-6700(97)00039-7 doi: 10.1016/S0079-6700(97)00039-7
14. [14]
  Kweon, H.; Yoo, M. K.; Park, I. K.; Kim, T. H.; Lee, H. C.; Lee, H. S.; Oh, J. S.; Akaike, T.; Cho, C. S. Biomaterials 2003, 24, 801. doi: 10.1016/S0142-9612(02)00370-8 doi: 10.1016/S0142-9612(02)00370-8
15. [15]
  Chen, L. S.; Hong, Y. X.; He, S. S.; Fan, Z.; Du, J. Z. Acta Phys. -Chim. Sin. 2020, 36, 1910059. doi: 10.3866/PKU.WHXB201910059
16. [16]
  Song, T.; Xi, Y. J.; Du, J. Z. Acta Polym. Sin. 2018, No. 1, 119. doi: 10.11777/j.issn1000-3304.2018.17229
17. [17]
  Lo, H. Y.; Kuo, H. T.; Huang, Y. Y. Artif. Organs 2010, 34, 648. doi: 10.1111/j.1525-1594.2009.00949.x doi: 10.1111/j.1525-1594.2009.00949.x
18. [18]
  Shi, D. L.; He, T.; Tang, W. J.; Li, H. Z.; Wang, C.; Zheng, M. Z.; Hu, J.; Song, X. H.; Ding, Y. M.; Chen, Y. Y.; et al. Neurosci. Lett. 2019, 694, 161. doi: 10.1016/j.neulet.2018.12.006 doi: 10.1016/j.neulet.2018.12.006
19. [19]
  Zhang, Q.; Jiang, Y.; Zhang, Y.; Ye, Z.; Tan, W.; Lang, M. Polym. Degrad. Stab. 2013, 98, 209. doi: 10.1016/j.polymdegradstab.2012.10.008 doi: 10.1016/j.polymdegradstab.2012.10.008
20. [20]
  Sun, H. F.; Mei, L.; Song, C. X.; Cui, X. M.; Wang, P. Y. Biomaterials 2006, 27, 1735. doi: 10.1016/j.biomaterials.2005.09.019 doi: 10.1016/j.biomaterials.2005.09.019
21. [21]
  Zou, Y. J.; He, S. S.; Du, J. Z. Chin. J. Polym. Sci. 2018, 36, 1239. doi: 10.1007/s10118-018-2156-1 doi: 10.1007/s10118-018-2156-1
22. [22]
  Liu, G. J.; Ding, J. F.; Hashimoto, T.; Kimishima, K.; Winnik, F. M.; Nigam, S. Chem. Mater. 1999, 11, 2233. doi: 10.1021/cm990184k doi: 10.1021/cm990184k
23. [23]
  Liao, Y. Y.; Fan, Z.; Du, J. Z. Acta Phys. -Chim. Sin. 2020, 36, 1912053. doi: 10.3866/PKU.WHXB201912053
24. [24]
  Yuan, K.; Zhou, X.; Du, J. Z. Acta Phys. -Chim. Sin. 2017, 33, 656. doi: 10.3866/PKU.WHXB201701162
25. [25]
  Xiao, Y. F.; Sun, H.; Du, J. Z. J. Am. Chem. Soc. 2017, 139, 7640. doi: 10.1021/jacs.7b03219 doi: 10.1021/jacs.7b03219
26. [26]
  Groschel, A. H.; Schacher, F. H.; Schmalz, H.; Borisov, O. V.; Zhulina, E. B.; Walther, A.; Muller, A. H. E. Nat. Commun. 2012, 3, 710. doi: 10.1038/ncomms1707 doi: 10.1038/ncomms1707
27. [27]
  Du, J. Z.; Chen, Y. M.; Zhang, Y. H.; Han, C. C.; Fischer, K.; Schmidt, M. J. Am. Chem. Soc. 2003, 125, 14710. doi: 10.1021/ja0368610 doi: 10.1021/ja0368610
28. [28]
  Qin, J. L.; Jiang, X. B.; Gao, L.; Chen, Y. M.; Xi, F. Macromolecules 2010, 43, 8094. doi: 10.1021/ma101639w doi: 10.1021/ma101639w
29. [29]
  Peng, B.; Liu, Y.; Shi, Y.; Li, Z. B.; Chen, Y. M. Soft Matter 2012, 8, 12002. doi: 10.1039/c2sm26638e doi: 10.1039/c2sm26638e
30. [30]
  Pitt, C. G.; Hendren, R. W.; Schindler, A.; Woodward, S. C. J. Controlled Release 1984, 1, 3. doi: 10.1016/0168-3659(84)90016-6 doi: 10.1016/0168-3659(84)90016-6
31. [31]
  Shen, J. Y.; Pan, X. Y.; Lim, C. H.; Chan-Park, M. B.; Zhu, X.; Beuerman, R. W. Biomacromolecules 2007, 8, 376. doi: 10.1021/bm060766c doi: 10.1021/bm060766c
32. [32]
  Gunatillake, P. A.; Adhikari, R. Eur. Cells Mater. 2003, 5, 1. doi: 10.22203/ecm.v005a01 doi: 10.22203/ecm.v005a01
33. [33]
  Kamada, J.; Koynov, K.; Corten, C.; Juhari, A.; Yoon, J. A.; Urban, M. W.; Balazs, A. C.; Matyjaszewski, K. Macromolecules 2010, 43, 4133. doi: 10.1021/ma100365n doi: 10.1021/ma100365n
34. [34]
  Tsarevsky, N. V.; Matyjaszewski, K. Macromolecules 2005, 38, 3087. doi: 10.1021/ma050020r doi: 10.1021/ma050020r
35. [35]
  Jiang, X. B.; Chen, Y. M.; Xi, F. Macromolecules 2010, 43, 7056. doi: 10.1021/ma101460n doi: 10.1021/ma101460n
36. [36]
  Wiltshire, J. T.; Qiao, G. G. Macromolecules 2006, 39, 9018. doi: 10.1021/ma0622027 doi: 10.1021/ma0622027
37. [37]
  Wiltshire, J. T.; Qiao, G. G. Macromolecules 2006, 39, 4282. doi: 10.1021/ma060712v doi: 10.1021/ma060712v
38. [38]
  Deng, G. H.; Tang, C. M.; Li, F. Y.; Jiang, H. F.; Chen, Y. M. Macromolecules 2010, 43, 1191. doi: 10.1021/ma9022197 doi: 10.1021/ma9022197
39. [39]
  Imato, K.; Nishihara, M.; Kanehara, T.; Amamoto, Y.; Takahara, A.; Otsuka, H. Angew. Chem., Int. Ed. 2012, 51, 1138. doi: 10.1002/anie.201104069 doi: 10.1002/anie.201104069
40. [40]
  Haraguchi, K.; Uyama, K.; Tanimoto, H. Macromol. Rapid Commun. 2011, 32, 1253. doi: 10.1002/marc.201100248 doi: 10.1002/marc.201100248
41. [41]
  Du, H.; Zha, G. Y.; Gao, L. L.; Wang, H.; Li, X. D.; Shen, Z. Q.; Zhu, W. P. Polym. Chem. 2014, 5, 4002. doi: 10.1039/c4py00030g doi: 10.1039/c4py00030g
42. [42]
  Atzet, S.; Curtin, S.; Trinh, P.; Bryant, S.; Ratner, B. Biomacromolecules 2008, 9, 3370. doi: 10.1021/bm800686h doi: 10.1021/bm800686h
43. [43]
  Darwis, D.; Mitomo, H.; Yoshii, F. Polym. Degrad. Stab. 1999, 65, 279. doi: 10.1016/S0141-3910(99)00017-8 doi: 10.1016/S0141-3910(99)00017-8
44. [44]
  Defize, T.; Riva, R.; Raquez, J.-M.; Dubois, P.; Jérôme, C.; Alexandre, M. Macromol. Rapid Commun. 2011, 32, 1264. doi: 10.1002/marc.201100250 doi: 10.1002/marc.201100250
45. [45]
  Riva, R.; Schmeits, S.; Stoffelbach, F.; Jérôme, C.; Jérôme, R.; Lecomte, P. Chem. Commun. 2005, No. 42, 5334. doi: 10.1039/b510282k doi: 10.1039/b510282k
46. [46]
  Chiu, F. C.; Wang, S. W.; Peng, K. Y.; Lee, R. S. Polymer 2012, 53, 3476. doi: 10.1016/j.polymer.2012.06.004 doi: 10.1016/j.polymer.2012.06.004
47. [47]
  Gupta, P.; Trenor, S. R.; Long, T. E.; Wilkes, G. L. Macromolecules 2004, 37, 9211. doi: 10.1021/ma048844g doi: 10.1021/ma048844g
48. [48]
  Rochette, J. M.; Ashby, V. S. Macromolecules 2013, 46, 2134. doi: 10.1021/ma302354a doi: 10.1021/ma302354a
49. [49]
  Belsito, D.; Bickers, D.; Bruze, M.; Calow, P.; Greim, H.; Hanifin, J. M.; Rogers, A. E.; Saurat, J. H.; Sipes, I. G.; Tagami, H. Food Chem. Toxicol. 2007, 45, S1. doi: 10.1016/j.fct.2007.09.087 doi: 10.1016/j.fct.2007.09.087
50. [50]
  Chen, S.; Qin, J. L.; Du, J. Z. Macromolecules 2020, 53, 3978. doi: 10.1021/acs.macromol.0c00252 doi: 10.1021/acs.macromol.0c00252
51. [51]
  Lenoir, S.; Riva, R.; Lou, X.; Detrembleur, C.; Jérôme, R.; Lecomte, P. Macromolecules 2004, 37, 4055. doi: 10.1021/ma035003l doi: 10.1021/ma035003l
52. [52]
  Chen, J. C.; Liu, M. Z.; Gong, H. H.; Huang, Y. J.; Chen, C. J. Phys. Chem. B 2011, 115, 14947. doi: 10.1021/jp208494w doi: 10.1021/jp208494w
53. [53]
  Cintas, P.; Barge, A.; Tagliapietra, S.; Boffa, L.; Cravotto, G. Nat. Protoc. 2010, 5, 607. doi: 10.1038/nprot.2010.1 doi: 10.1038/nprot.2010.1
54. [54]
  Ge, T.; Pierce, F.; Perahia, D.; Grest, G. S.; Robbins, M. O. Phys. Rev. Lett. 2013, 110, 098301. doi: 10.1103/PhysRevLett.110.098301 doi: 10.1103/PhysRevLett.110.098301
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