Citation: Wei Chunrong, Wang Fei, Pei Weihua, Liu Zhiduo, Mao Xurui, Zhao Hongze, Wang Sikai, Wang Yijun, Yang Xiaowei, Liu Yuanyuan, Zhao Shanshan, Gui Qiang, Chen Hongda. Light-Induced Noise Reduction of Lightly Doped Silicon-based Neural Electrode[J]. Acta Physico-Chimica Sinica, ;2020, 36(12): 200503. doi: 10.3866/PKU.WHXB202005033 shu

Light-Induced Noise Reduction of Lightly Doped Silicon-based Neural Electrode

Wei Chunrong ^1,2,4 ,
Wang Fei ^1,2,4 ,
Pei Weihua ^1,2,4,, ,
Liu Zhiduo ^1,2,4 ,
Mao Xurui ¹ ,
Zhao Hongze ^1,2,4 ,
Wang Sikai ^1,2,4 ,
Wang Yijun ^1,2,4 ,
Yang Xiaowei ^1,2,4 ,
Liu Yuanyuan ^3,4 ,
Zhao Shanshan ⁵ ,
Gui Qiang ^1,2,4 ,
Chen Hongda ^1,2

1.
The State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, P. R. China
2.
CAS Center for Excellence in Brain Science and Intelligence Technology, Beijing 100083, P. R. China
3.
Engineering Research Center for Semiconductor Integrated Technology, Beijing 100083, P. R. China
4.
University of Chinese Academy of Sciences, Beijing 100049, P. R. China
5.
School of Information Technology and Engineering, Tianjin University of Technology and Education, Tianjin 300222, P. R. China

Corresponding author: Pei Weihua, peiwh@semi.ac.cn
Received Date: 12 May 2020
Revised Date: 10 June 2020
Accepted Date: 12 June 2020
Available Online: 15 June 2020
Fund Project: the National Key Technologies Research and Development Program of China 2016YFB0402405the Strategic Priority Research Program of Chinese Academy of Sciences Pilot Project XDB32040200the National Natural Science Foundation of China 61671424The project was supported by the National Key Technologies Research and Development Program of China (2017YFA0205903, 2017YFA0701100, 2016YFB0402405); the National Natural Science Foundation of China (61634006, 61671424); the Strategic Priority Research Program of Chinese Academy of Sciences Pilot Project (XDB32030100, XDB32040200); the Key Research Programs of Frontier Sciences, CAS (QYZDY-SSW-JSC004)the National Key Technologies Research and Development Program of China 2017YFA0205903the Key Research Programs of Frontier Sciences, CAS QYZDY-SSW-JSC004the National Key Technologies Research and Development Program of China 2017YFA0701100the Strategic Priority Research Program of Chinese Academy of Sciences Pilot Project XDB32030100the National Natural Science Foundation of China 61634006

Silicon-based neural probes are practical tools for recording neural cell firing. A single silicon-based needle with a width of only 70 μm, prepared using the standard complementary metal-oxide-semiconductor (CMOS) process technology, can contain thousands of electrode-recording sites. Optogenetics has made control over neuronal activity more precise. By recording the electrical activity of neurons stimulated by light, more information about brain activity can be recorded and analyzed. When yellow light or blue light is used to stimulate neurons, the photon energy is greater than the forbidden bandwidth of the silicon substrate, and the valence-band electrons are excited to the conduction band, generating electron-hole pairs. The photoinduced carrier in the silicon substrate severely disrupts the probe's signal-to-noise ratio. Decreasing the disturbance caused by light is a pragmatic way to execute recording and stimulating simultaneously. The traditional noise reduction method involves using heavily doped silicon as the substrate, reducing the carrier life by increasing the impurity concentration, and then reducing the noise of the silicon electrode under illumination. However, the heavily doped silicon substrate has more lattice defects than its lightly doped counterparts, which makes the silicon electrode fragile, and this method is not compatible with the standard CMOS process technology. On analyzing the photoinduced noise mechanism of manufacturing electrodes on lightly doped silicon substrates, we found that the inhomogeneous distribution of carriers generated by light excitation polarizes lightly doped silicon substrates. The potential caused by photoinduced polarization will affect the electrodes fabricated on it. Metalizing and grounding the lightly doped silicon substrate will effectively decrease the polarization potential. On using this method, the noise amplitude caused by the illumination can drop to 0.87% of the original value. To ensure an appropriate firing rate of neurons, the photo-stimulation frequency was chosen to be 20 Hz. Under the illumination of 1 mW·mm^-2, the background noise of the electrode could be controlled below 45 μV, which meets the needs for general optogenetics applications. Modification of the lightly doped silicon substrate will meet the requirements of the neural electrode for optogenetics applications. Unlike the traditional method of reducing light-induced noise by heavily doping the entire substrate, the noise reduction method of lightly doped silicon substrate is compatible with the standard CMOS process technology. It provides a noise cancellation method for the preparation of silicon-based neural microelectrodes with dense recording sites and high channel count using standard CMOS processes.
- Light-induced noise,
- Photoinduced carrier,
- Optogenetics,
- Lightly doped,
- Silicon-based neural probe
1. [1]
  Jun, J. J.; Steinmetz, N. A.; Siegle, J. H.; Denman, D. J.; Bauza, M.; Barbarits, B.; Lee, A. K.; Anastassiou, C. A.; Andrei, A.; Aydin, C.; et al. Nature 2017, 551 (7679), 232. doi: 10.1038/nature24636 doi: 10.1038/nature24636
2. [2]
  Najafi, K.; Ji, J.; Wise, K. D. IEEE Trans. Biomed. Eng. 1990, 37 (1), 1. doi: 10.1109/10.43605 doi: 10.1109/10.43605
3. [3]
  Aldaoud, A.; Soto-Breceda, A.; Tong, W.; Conductier, G.; Tonta, M. A.; Coleman, H. A.; Parkington, H. C.; Clarke, I.; Redoute, J. M.; Garrett, D. J.; et al. Sens. Actuators A-Phys. 2018, 271, 201. doi: 10.1016/j.sna.2017.12.051 doi: 10.1016/j.sna.2017.12.051
4. [4]
  McGregor, J. E.; Godat, T.; Dhakal, K. R.; Parkins, K.; Strazzeri, J. M.; Bateman, B. A.; Fischer, W. S.; Williams, D. R.; Merigan, W. H. Nat. Commun. 2020, 11 (1), 1703. doi: 10.1038/s41467-020-15317-6 doi: 10.1038/s41467-020-15317-6
5. [5]
  Tung, J. K.; Berglund, K.; Gross, R. E. Brain Stimul. 2016, 9 (6), 801. doi: 10.1016/j.brs.2016.06.055 doi: 10.1016/j.brs.2016.06.055
6. [6]
  Royer, S.; Zemelman, B. V.; Barbic, M.; Losonczy, A.; Buzsaki, G.; Magee, J. C. Eur. J. Neurosci. 2010, 31 (12), 2279. doi: 10.1111/j.1460-9568.2010.07250.x doi: 10.1111/j.1460-9568.2010.07250.x
7. [7]
  Wu, F.; Stark, E.; Ku, P. C.; Wise, K. D.; Buzsáki, G.; Yoon, E. Neuron 2015, 88 (6), 1136. doi: 10.1016/j.neuron.2015.10.032 doi: 10.1016/j.neuron.2015.10.032
8. [8]
  Bai, Q.; Wise, K. D.; Anderson, D. J. IEEE Trans. Biomed. Eng. 2000, 47 (3), 281. doi: 10.1109/10.827288 doi: 10.1109/10.827288
9. [9]
  Scholvin, J.; Kinney, J. P.; Bernstein, J. G.; Moore-Kochlacs, C.; Kopell, N.; Fonstad, C. G.; Boyden, E. S. IEEE Trans. Biomed. Eng. 2016, 63 (1), 120. doi: 10.1109/TBME.2015.2406113 doi: 10.1109/TBME.2015.2406113
10. [10]
  Law, M. E.; Solley, E.; Liang, M.; Burk, D. E. IEEE Electron Device Lett. 1991, 12 (8), 401. doi: 10.1109/55.119145 doi: 10.1109/55.119145
11. [11]
  Connolly, A. T.; Vetter, R. J.; Hetke, J. F.; Teplitzky, B. A.; Kipke, D. R.; Pellinen, D. S.; Anderson, D. J.; Baker, K. B.; Vitek, J. L.; Johnson, M. D. IEEE Trans. Biomed. Eng. 2016, 63 (1), 148. doi: 10.1109/TBME.2015.2492921 doi: 10.1109/TBME.2015.2492921
12. [12]
  Blanche, T. J.; Spacek, M. A.; Hetke, J. F.; Swindale, N. V. J. Neurophysiol. 2005, 93 (5), 2987. doi: 10.1152/jn.01023.2004 doi: 10.1152/jn.01023.2004
13. [13]
  Chen, S. Y.; Pei, W. H.; Zhao, H.; Gui, Q.; Tang, R. Y.; Chen, Y. F.; Fang, X. L.; Hong, B.; Gao, X. R.; Chen, H. D. Sci. China Inf. Sci. 2014, 57 (5), 1. doi: 10.1007/s11432-013-4846-1 doi: 10.1007/s11432-013-4846-1
14. [14]
  Chen, S.; Pei, W.; Gui, Q.; Tang, R.; Chen, Y.; Zhao, S.; Wang, H.; Chen, H. Sens. Actuators A-Phys. 2013, 193, 141. doi: 10.1016/j.sna.2013.01.033 doi: 10.1016/j.sna.2013.01.033
15. [15]
  Norlin, P.; Kindlundh, M.; Mouroux, A.; Yoshida, K.; Hofmann, U. G. J. Micromech. Microeng. 2002, 12 (4), 414. doi: 10.1088/0960-1317/12/4/312 doi: 10.1088/0960-1317/12/4/312
16. [16]
  Stark, E.; Roux, L.; Eichler, R.; Senzai, Y.; Royer, S.; Buzsáki, G. Neuron 2014, 83 (2), 467. doi: 10.1016/j.neuron.2014.06.023 doi: 10.1016/j.neuron.2014.06.023
17. [17]
  Ferguson, J. E.; Boldt, C.; Redish, A. D. Sens. Actuators A-Phys. 2009, 156 (2), 388. doi: 10.1016/j.sna.2009.10.001 doi: 10.1016/j.sna.2009.10.001
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