Citation: Xie Fan, Xi Ye, Xu Qingda, Liu Jingquan. Utah Neural Electrode Technology for Brain-Computer Interface[J]. Acta Physico-Chimica Sinica, ;2020, 36(12): 200301. doi: 10.3866/PKU.WHXB202003014 shu

Utah Neural Electrode Technology for Brain-Computer Interface

National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Department of Micro/Nano-electronics, Shanghai Jiao Tong University, Shanghai 200240, P. R. China

Corresponding author: Liu Jingquan, jqliu@sjtu.edu.cn
Received Date: 5 March 2020
Revised Date: 11 May 2020
Accepted Date: 11 May 2020
Available Online: 14 May 2020
Fund Project: the Research Program of Shanghai Science and Technology Committee, China 17JC1402800the Program of Shanghai Academic/Technology Research Leader, China 18XD1401900the National Natural Science Foundation of China 61728402the National Key R & D Program of China 2017YFB1002501The project was supported by the National Key R & D Program of China (2017YFB1002501), the National Natural Science Foundation of China (61728402), the Research Program of Shanghai Science and Technology Committee, China (17JC1402800), the Program of Shanghai Academic/Technology Research Leader, China (18XD1401900)

A human brain is composed of a large number of interconnected neurons forming a neural network. To study the functional mechanism of the neural network, it is necessary to record the activity of individual neurons over a large area simultaneously. Brain-computer interface (BCI) refers to the connection established between the human/animal brain and computers/other electronic devices, which enables direct interaction between the brain and external devices. It plays an important role in understanding, protecting, and simulating the brain, especially in helping patients with neurological disorders to restore their impaired motor and sensory functions. Neural electrodes are electrophysiological devices that form the core of BCI, which convert neuronal electrical signals (carried by ions) into general electrical signals (carried by electrons). They can record or interfere with the state of neural activity. The Utah Electrode Array (UEA) designed by the University of Utah is a mainstream neural electrode fabricated by bulk micromachining. Its unique three-dimensional needle-like structure enables each electrode to obtain high spatiotemporal resolution and good insulation between each other. After implantation, the tip of each electrode affects only a small group of neurons around it even allowing to record the action potential of a single neuron. The availability of a large number of electrodes, high quality of signals, and long service life has made UEA the first choice for collecting neuronal signals. Moreover, UEA is the only implantable neural electrode that can record signals in the human cerebral cortex. This article mainly serves as an introduction to the construction, manufacturing process, and functioning of UEA, with a focus on the research progress in fabricating high-density electrode arrays, wireless neural interfaces, and optrode arrays using silicon, glass, and metal as that material of construction. We also discuss the surface modification techniques that can be used to reduce the electrode impedance, minimize the rejection by brain tissue, and improve the corrosion resistance of the electrode. In addition, we summarize the clinical applications where patients can control external devices and get sensory feedback by implanting UEA. Furthermore, we discuss the challenges faced by existing electrodes such as the difficulty in increasing electrode density, poor response of integrated wireless neural interface, and the problems of biocompatibility. To achieve stability and durability of the electrode, advancements in both material science and manufacturing technology are required. We hope that this review can broaden the scope of ideas for the development of UEA. The realization of a fully implantable neural microsystem can contribute to an improved understanding of the functional mechanisms of the neural network and treatment of neurological diseases.
- Neural electrode,
- Implantable,
- Utah electrode array,
- Surface modification,
- Biocompatibility
1. [1]
  Nair, P. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 18343. doi: 10.1073/pnas.1319310110 doi: 10.1073/pnas.1319310110
2. [2]
  Fetz, E. E. Prog. Brain Res. 2015, 218, 241. doi: 10.1016/bs.pbr.2015.01.001 doi: 10.1016/bs.pbr.2015.01.001
3. [3]
  Hochberg, L. R.; Serruya, M. D.; Friehs, G. M.; Mukand, J. A.; Saleh, M.; Caplan, A. H.; Branner, A.; Chen, D.; Penn, R. D.; Donoghue, J. P. Nature 2006, 442, 164. doi: 10.1038/nature04970 doi: 10.1038/nature04970
4. [4]
  Hochberg, L. R.; Bacher, D.; Jarosiewicz, B.; Masse, N. Y.; Simeral, J. D.; Vogel, J.; Haddadin, S.; Liu, J.; Cash, S. S.; van der Smagt, P.; et al. Nature 2012, 485, 372. doi: 10.1038/nature11076 doi: 10.1038/nature11076
5. [5]
  Deuschl, G.; Schade-Brittinger, C.; Krack, P.; Volkmann, J.; Schäfer, H.; Bötzel, K.; Daniels, C.; Deutschländer, A.; Dillmann, U.; Eisner, W.; et al. N. Engl. J. Med. 2006, 355, 896. doi: 10.1056/NEJMoa060281 doi: 10.1056/NEJMoa060281
6. [6]
  Boon, P.; Vonck, K.; De Herdt, V.; Van Dycke, A.; Goethals, M.; Goossens, L.; Van Zandijcke, M.; De Smedt, T.; Dewaele, I.; Achten, R.; et al. Epilepsia 2007, 48, 1551. doi: 10.1111/j.1528-1167.2007.01005.x doi: 10.1111/j.1528-1167.2007.01005.x
7. [7]
  Nicolelis, M. A. L.; Ghazanfar, A. A.; Faggin, B. M.; Votaw, S.; Oliveira, L. M. O. Neuron 1997, 18, 529. doi: 10.1016/S0896-6273(00)80295-0 doi: 10.1016/S0896-6273(00)80295-0
8. [8]
  Nicolelis, M. A. L.; Dimitrov, D.; Carmena, J. M.; Crist, R.; Lehew, G.; Kralik, J. D.; Wise, S. P. Proc. Natl. Acad. Sci. U. S. A. 2003, 100, 11041. doi: 10.1073/pnas.1934665100 doi: 10.1073/pnas.1934665100
9. [9]
  Wise, K. D.; Najafi, K. Science 1991, 254, 1335. doi: 10.1126/science.1962192 doi: 10.1126/science.1962192
10. [10]
  Daryl, R. K.; Rio, J. V.; Justin, C. W.; Jamille, F. H. IEEE Trans. Neural Syst. Rehabil. Eng. 2003, 11, 151. doi: 10.1109/TNSRE.2003.814443 doi: 10.1109/TNSRE.2003.814443
11. [11]
  Wise, K. D.; Sodagar, A. M.; Yao, Y.; Gulari, M. N.; Perlin, G. E.; Najafi, K. Proc. IEEE 2008, 96, 1184. doi: 10.1109/JPROC.2008.922564 doi: 10.1109/JPROC.2008.922564
12. [12]
  Normann, R. A.; Campbell, P. K.; Jones, K. E. A silicon-based, Three-dimensional neural Interface: Manufacturing Processes for an Intracortical Electrode array. In: Images of the Twenty-First Century, Proceedings of the Annual International Engineering in Medicine and Biology Society, Seattle, WA, USA, 1989; pp. 939-940.
13. [13]
  Campbell, P. K.; Jones, K. E.; Huber, R. J.; Horch, K. W.; Normann, R. A. IEEE Trans. Biomed. Eng. 1991, 38, 758. doi: 10.1109/10.83588 doi: 10.1109/10.83588
14. [14]
  Normann, R. A. Nat. Clin. Pract. Neurol. 2007, 3, 444. doi: 10.1038/ncpneuro0556 doi: 10.1038/ncpneuro0556
15. [15]
  Bhandari, R.; Negi, S.; Solzbacher, F. Biomed. Microdevices 2010, 12, 797. doi: 10.1007/s10544-010-9434-1 doi: 10.1007/s10544-010-9434-1
16. [16]
  Branner, A.; Normann, R. A. Brain Res. Bull. 2000, 51, 293. doi: 10.1016/S0361-9230(99)00231-2 doi: 10.1016/S0361-9230(99)00231-2
17. [17]
  Branner, A.; Stein, R. B.; Normann, R. A. J. Neurophysiol. 2001, 85, 1585. doi: 10.1152/jn.2001.85.4.1585 doi: 10.1152/jn.2001.85.4.1585
18. [18]
  Bhandari, R.; Negi, S.; Rieth, L.; Normann, R. A.; Solzbacher, F. Sens. Actuator A-Phys. 2008, 145, 123. doi: 10.1016/j.sna.2007.10.072 doi: 10.1016/j.sna.2007.10.072
19. [19]
  Buzsáki, G. Nat. Neurosci. 2004, 7, 446. doi: 10.1038/nn1233 doi: 10.1038/nn1233
20. [20]
  House, P. A.; Macdonald, J. D.; Tresco, P. A.; Normann, R. A. Neurosurg. Focus 2006, 20, 1. doi: 10.3171/foc.2006.20.5.5 doi: 10.3171/foc.2006.20.5.5
21. [21]
  Biran, R.; Martin, D. C.; Tresco, P. A. J. Biomed. Mater. Res. Part A 2007, 82, 169. doi: 10.1002/jbm.a.31138 doi: 10.1002/jbm.a.31138
22. [22]
  Christensen, M. B.; Pearce, S. M.; Ledbetter, N. M.; Warren, D. J.; Clark, G. A.; Tresco, P. A. Acta Biomater. 2014, 10, 4650. doi: 10.1016/j.actbio.2014.07.010 doi: 10.1016/j.actbio.2014.07.010
23. [23]
  Pei, W. H. Sci. Technol. Rev. 2018, 36, 77. doi: 10.3981/j.issn.1000-7857.2018.06.009
24. [24]
  Wei, C. R.; Pei, W. H. Chin. J. Anal. Chem. 2019, 47, 1455. doi: 10.19756/j.issn.0253-3820.191430
25. [25]
  Shandhi, M. M. H.; Leber, M.; Hogan, A.; Bhandari, R.; Negi, S. A Novel Method of Fabricating Hhigh Channel Density Neural Array for Large Neuronal Mapping. In: Transducers, Anchorage, Alaska, USA, June 21-25, 2015; IEEE: New York, 2015.
26. [26]
  Wark, H. A. C.; Sharma, R.; Mathews, K. S.; Fernandez, E.; Yoo, J.; Christensen, B.; Tresco, P.; Rieth, L.; Solzbacher, F.; Normann, R. A.; et al. J. Neural Eng. 2013, 10, 45003. doi: 10.1088/1741-2560/10/4/045003 doi: 10.1088/1741-2560/10/4/045003
27. [27]
  Mathews, K. S.; Wark, H. A. C.; Normann, R. A. Muscle Nerve 2014, 50, 417. doi: 10.1002/mus.24171 doi: 10.1002/mus.24171
28. [28]
  Fujishiro, A.; Kaneko, H.; Kawashima, T.; Ishida, M.; Kawano, T. Sci. Rep. 2014, 4, 1. doi: 10.1038/srep04868 doi: 10.1038/srep04868
29. [29]
  Kim, S.; Bhandari, R.; Klein, M.; Negi, S.; Rieth, L.; Tathireddy, P.; Toepper, M.; Oppermann, H.; Solzbacher, F. Biomed. Microdevices 2009, 11, 453. doi: 10.1007/s10544-008-9251-y doi: 10.1007/s10544-008-9251-y
30. [30]
  Yin, M.; Borton, D. A.; Komar, J.; Agha, N.; Lu, Y.; Li, H.; Laurens, J.; Lang, Y.; Li, Q.; Bull, C.; et al. Neuron 2014, 84, 1170. doi: 10.1016/j.neuron.2014.11.010 doi: 10.1016/j.neuron.2014.11.010
31. [31]
  Sharma, A.; Rieth, L.; Tathireddy, P.; Harrison, R.; Oppermann, H.; Klein, M.; Töpper, M.; Jung, E.; Normann, R.; Clark, G.; et al. J. Neural Eng. 2011, 8, 45004. doi: 10.1088/1741-2560/8/4/045004 doi: 10.1088/1741-2560/8/4/045004
32. [32]
  Deisseroth, K. Nat. Methods 2010, 8, 26. doi: 10.1038/NMETH.F.324 doi: 10.1038/NMETH.F.324
33. [33]
  Boyden, E. S.; Zhang, F.; Bamberg, E.; Nagel, G.; Deisseroth, K. Nat. Neurosci. 2005, 8, 1263. doi: 10.1038/nn1525 doi: 10.1038/nn1525
34. [34]
  Han, X.; Qian, X.; Bernstein, J. G.; Zhou, H.; Franzesi, G. T.; Stern, P.; Bronson, R. T.; Graybiel, A. M.; Desimone, R.; Boyden, E. S. Neuron 2009, 62, 191. doi: 10.1016/j.neuron.2009.03.011 doi: 10.1016/j.neuron.2009.03.011
35. [35]
  Goncalves, S. B.; Ribeiro, J. F.; Silva, A. F.; Costa, R. M.; Correia, J. H. J. Neural Eng. 2017, 14, 41001. doi: 10.1088/1741-2552/aa7004 doi: 10.1088/1741-2552/aa7004
36. [36]
  Abaya, T. V F.; Blair, S.; Tathireddy, P.; Rieth, L.; Solzbacher, F. Biomed. Opt. Express 2012, 3, 3087. doi: 10.1364/BOE.3.003087 doi: 10.1364/BOE.3.003087
37. [37]
  Abaya, T. V. F.; Diwekar, M.; Blair, S.; Tathireddy, P.; Rieth, L.; Solzbacher, F. J. Biomed. Opt. 2014, 19, 15006. doi: 10.1117/1.JBO.19.1.015006 doi: 10.1117/1.JBO.19.1.015006
38. [38]
  Scharf, R.; Reiche, C. F.; Mcalinden, N.; Cheng, Y.; Xie, E.; Sharma, R.; Tathireddy, P.; Rieth, L.; Mathieson, K.; Blair, S. A Compact Integrated Device for Spatially Selective Optogenetic Neural Stimulation Based on the Utah Optrode Array. In Proceedings of SPIE, Conference on Optogenetics and Optical Manipulation, San Francisco, CA, January 27-28, 2018; Mohanty, S. K.; Thakor, N. V.; Jansen, E. D., Eds.; SPIE: Bellingham, 2018.
39. [39]
  Fofonoff, T. A.; Martel, S. M.; Hatsopoulos, N. G.; Donoghue, J. P.; Hunter, I. W. Ieee T Bio-Med Eng. 2004, 51, 890. doi: 10.1109/TBME.2004.826679 doi: 10.1109/TBME.2004.826679
40. [40]
  Goncalves, S. B.; Peixoto, A. C.; Rodrigues, J. A.; Silva, A. F.; Correia, J. H. Procedia Eng. 2014, 87, 939. doi: 10.1016/j.proeng.2014.11.311 doi: 10.1016/j.proeng.2014.11.311
41. [41]
  Li, J.; Huang, D.; Chen, Y.; Li, Z. Low-Cost, Metal-Based Micro-Needle Electrode Array (M-MNEA): A Three-Dimensional Intracortical Neural Interface. In Transducers, Berlin, GERMANY, June 23-27, 2019; IEEE: Piscataway, 2019.
42. [42]
  Barrese, J. C.; Rao, N.; Paroo, K.; Triebwasser, C.; Vargas-Irwin, C.; Franquemont, L.; Donoghue, J. P. J. Neural Eng. 2013, 10, 66014. doi: 10.1088/1741-2560/10/6/066014 doi: 10.1088/1741-2560/10/6/066014
43. [43]
  Prasad, A.; Xue, Q.; Dieme, R.; Sankar, V.; Mayrand, R. C.; Nishida, T.; Streit, W. J.; Sanchez, J. C. Front. Neuroeng. 2014, 7, 2. doi: 10.3389/fneng.2014.00002 doi: 10.3389/fneng.2014.00002
44. [44]
  Kozai, T. D. Y.; Catt, K.; Li, X.; Gugel, Z. V.; Olafsson, V. T.; Vazquez, A. L.; Cui, X. T. Biomaterials 2015, 37, 25. doi: 10.1016/j.biomaterials.2014.10.040 doi: 10.1016/j.biomaterials.2014.10.040
45. [45]
  Ferguson, M.; Sharma, D.; Ross, D.; Zhao, F. Adv. Healthc. Mater. 2019, 8, 1900558. doi: 10.1002/adhm.201900558 doi: 10.1002/adhm.201900558
46. [46]
  Fernã Ndez, E.; Greger, B.; House, P. A.; Aranda, I.; Botella, C.; Albisua, J.; Soto-Sã Nchez, C.; Alfaro, A.; Normann, R. A. Front. Neuroeng. 2014, 7, 24. doi: 10.3389/fneng.2014.00024 doi: 10.3389/fneng.2014.00024
47. [47]
  Rui, Y.; Liu, J.; Wang, Y.; Yang, C. Microsyst. Technol. 2011, 17, 437. doi: 10.1007/s00542-011-1279-x doi: 10.1007/s00542-011-1279-x
48. [48]
  Heim, M.; Yvert, B.; Kuhn, A. J. Physiol.-Paris 2012, 106, 137. doi: 10.1016/j.jphysparis.2011.10.001 doi: 10.1016/j.jphysparis.2011.10.001
49. [49]
  Boehler, C.; Stieglitz, T.; Asplund, M. Biomaterials 2015, 67, 346. doi: 10.1016/j.biomaterials.2015.07.036 doi: 10.1016/j.biomaterials.2015.07.036
50. [50]
  Negi, S.; Bhandari, R.; Rieth, L.; Solzbacher, F. Biomed. Mater. 2010, 5, 15007. doi: 10.1088/1748-6041/5/1/015007 doi: 10.1088/1748-6041/5/1/015007
51. [51]
  Cogan, S. F.; Ehrlich, J.; Plante, T. D.; Smirnov, A.; Shire, D. B.; Gingerich, M.; Rizzo, J. F. J. Biomed. Mater. Res. Part B 2009, 89, 353. doi: 10.1002/jbm.b.31223 doi: 10.1002/jbm.b.31223
52. [52]
  Slavcheva, E.; Vitushinsky, R.; Mokwa, W.; Schnakenberg, U. J. Electrochem. Soc. 2004, 151, E226. doi: 10.1149/1.1747881 doi: 10.1149/1.1747881
53. [53]
  Cui, X.; Lee, V. A.; Raphael, Y.; Wiler, J. A.; Hetke, J. F.; Anderson, D. J.; Martin, D. C. J. Biomed. Mater. Res. 2001, 56, 261. doi: 10.1002/1097-4636(200108)56:2 < 261::AID-JBM1094 > 3.0.CO; 2-I doi: 10.1002/1097-4636(200108)56:2<261::AID-JBM1094>3.0.CO;2-I
54. [54]
  Cui, X.; Martin, D. C. Sens. Actuator B-Chem. 2003, 89, 92. doi: 10.1016/s0925-4005(02)00448-3 doi: 10.1016/s0925-4005(02)00448-3
55. [55]
  Du, Z. J.; Luo, X.; Weaver, C. L.; Cui, X. T. J. Mater. Chem. C 2015, 3, 6515. doi: 10.1039/C5TC00145E doi: 10.1039/C5TC00145E
56. [56]
  Wang, L.; Wang, M.; Ge, C.; Ji, B.; Guo, Z.; Wang, X.; Yang, B.; Li, C.; Liu, J. Biosens. Bioelectron. 2019, 145, 111661. doi: 10.1016/j.bios.2019.111661 doi: 10.1016/j.bios.2019.111661
57. [57]
  Wang, M.; Ji, B.; Gu, X.; Tian, C.; Kang, X.; Yang, B.; Wang, X.; Chen, X.; Li, C.; Liu, J. Biosens. Bioelectron. 2017, 99, 99. doi: 10.1016/j.bios.2017.07.030 doi: 10.1016/j.bios.2017.07.030
58. [58]
  Kojabad, Z. D.; Shojaosadati, S. A.; Firoozabadi, S. M.; Hamedi, S. J. Solid State Electrochem. 2019, 23, 1533. doi: 10.1007/s10008-019-04245-1 doi: 10.1007/s10008-019-04245-1
59. [59]
  Abidian, M. R.; Corey, J. M.; Kipke, D. R.; Martin, D. C. Small 2010, 6, 421. doi: 10.1002/smll.200901868 doi: 10.1002/smll.200901868
60. [60]
  Keefer, E.W.; Botterman, B. R.; Romero, M. I.; Rossi, A.F.; Gross, G. W. Nat. Nanotechnol. 2008, 3, 434. doi: 10.1038/nnano.2008.174 doi: 10.1038/nnano.2008.174
61. [61]
  Burblies, N.; Schulze, J.; Schwarz, H.; Kranz, K.; Motz, D.; Vogt, C.; Lenarz, T.; Warnecke, A.; Behrens, P. Plos One 2016, 11, e158571. doi: 10.1371/journal.pone.0158571 doi: 10.1371/journal.pone.0158571
62. [62]
  Cogan, S. F. Annu. Rev. Biomed. Eng. 2008, 10, 275. doi: 10.1146/annurev.bioeng.10.061807.160518 doi: 10.1146/annurev.bioeng.10.061807.160518
63. [63]
  Luo, X.; Weaver, C. L.; Zhou, D. D.; Greenberg, R.; Cui, X. T. Biomaterials 2011, 32, 5551. doi:10.1016/j.biomaterials.2011.04.051 doi: 10.1016/j.biomaterials.2011.04.051
64. [64]
  Dee, K. C.; Puleo, D. A.; Bizis, R. An Introduction to Tissue-Biomaterial Interactions, 1st ed.; John Wiley & Sons: NJ, 2002; pp 15-35.
65. [65]
  Lok, J.; Leung, W.; Murphy, S.; Butler, W.; Noviski, N.; Lo, E. H. Acta Neurochir. 2011, 111, 63. doi: 10.1007/978-3-7091-0693-8_11 doi: 10.1007/978-3-7091-0693-8_11
66. [66]
  Ceyssens, F.; Deprez, M.; Turner, N.; Kil, D.; van Kuyck, K.; Welkenhuysen, M.; Nuttin, B.; Badylak, S.; Puers, R. J. Neural Eng. 2017, 14, 14001. doi: 10.1088/1741-2552/14/1/014001 doi: 10.1088/1741-2552/14/1/014001
67. [67]
  Azemi, E.; Lagenaur, C. F.; Cui, X. T. Biomaterials 2011, 32, 681. doi: 10.1016/j.biomaterials.2010.09.033 doi: 10.1016/j.biomaterials.2010.09.033
68. [68]
  Eles, J. R.; Vazquez, A. L.; Snyder, N. R.; Lagenaur, C.; Murphy, M. C.; Kozai, T. D. Y.; Cui, X. T. Biomaterials 2017, 113, 279. doi: 10.1016/j.biomaterials.2016.10.054 doi: 10.1016/j.biomaterials.2016.10.054
69. [69]
  Kolarcik, C. L.; Bourbeau, D.; Azemi, E.; Rost, E.; Zhang, L.; Lagenaur, C. F.; Weber, D. J.; Cui, X. T. Acta Biomater. 2012, 8, 3561. doi: 10.1016/j.actbio.2012.06.034 doi: 10.1016/j.actbio.2012.06.034
70. [70]
  Capeletti, L. B.; Cardoso, M. B.; Dos Santos, J. H. Z.; He, W. ACS Appl. Mater. Interfaces 2016, 8, 27553. doi: 10.1021/acsami.6b09393 doi: 10.1021/acsami.6b09393
71. [71]
  Lago, N.; Ceballos, D.; J Rodrı́guez, F.; Stieglitz, T.; Navarro, X. Biomaterials 2005, 26, 2021. doi: 10.1016/j.biomaterials.2004.06.025 doi: 10.1016/j.biomaterials.2004.06.025
72. [72]
  Loeb, G. E.; Bak, M. J.; Salcman, M.; Schmidt, E. M. IEEE Trans. Biomed. Eng. 1977, BME-24, 121. doi: 10.1109/TBME.1977.326115 doi: 10.1109/TBME.1977.326115
73. [73]
  Hsu, J.; Rieth, L.; Normann, R. A.; Tathireddy, P.; Solzbacher, F. IEEE Trans. Biomed. Eng. 2009, 56, 23. doi: 10.1109/TBME.2008.2002155 doi: 10.1109/TBME.2008.2002155
74. [74]
  Wu, J.; Pike, R. T.; Wong, C. P.; Kim, N. P.; Tanielian, M. H. IEEE Trans. Adv. Packag. 2000, 23, 721. doi: 10.1109/6040.883764 doi: 10.1109/6040.883764
75. [75]
  Hsu, J.; Tathireddy, P.; Rieth, L.; Normann, A. R.; Solzbacher, F. Thin Solid Films 2007, 516, 34. doi:10.1016/j.tsf.2007.04.050 doi: 10.1016/j.tsf.2007.04.050
76. [76]
  Cogan, S. F.; Edell, D. J.; Guzelian, A. A.; Ying, P. L.; Edell, R. J. Biomed. Mater. Res. Part A 2003, 67A, 856. doi: 10.1002/jbm.a.10152 doi: 10.1002/jbm.a.10152
77. [77]
  Roy, R. K.; Lee, K. J. Biomed. Mater. Res. Part B 2007, 83, 72. doi: 10.1002/jbm.b.30768 doi: 10.1002/jbm.b.30768
78. [78]
  Winslow, B. D.; Christensen, M. B.; Yang, W.; Solzbacher, F.; Tresco, P. A. Biomaterials 2010, 31, 9163. doi: 10.1016/j.biomaterials.2010.05.050 doi: 10.1016/j.biomaterials.2010.05.050
79. [79]
  Wang, R.; Zhao, W.; Wang, W.; Li, Z. J. Microelectromech. Syst. 2012, 21, 1084. doi: 10.1109/JMEMS.2012.2203790 doi: 10.1109/JMEMS.2012.2203790
80. [80]
  Xie, X.; Rieth, L.; Williams, L.; Negi, S.; Bhandari, R.; Caldwell, R.; Sharma, R.; Tathireddy, P.; Solzbacher, F. J. Neural Eng. 2014, 11, 26016. doi: 10.1088/1741-2560/11/2/026016 doi: 10.1088/1741-2560/11/2/026016
81. [81]
  Joshi-Imre, A.; Black, B. J.; Abbott, J.; Kanneganti, A.; Rihani, R.; Chakraborty, B.; Danda, V. R.; Maeng, J.; Sharma, R.; Rieth, L.; et al. J. Neural Eng. 2019, 16, 46006. doi: 10.1088/1741-2552/ab1bc8 doi: 10.1088/1741-2552/ab1bc8
82. [82]
  Castellini, C.; Artemiadis, P.; Wininger, M.; Ajoudani, A.; Alimusaj, M.; Bicchi, A.; Caputo, B.; Craelius, W.; Dosen, S.; Englehart, K.; et al. Front. Neurorobotics 2014, 8, 1. doi: 10.3389/fnbot.2014.00022 doi: 10.3389/fnbot.2014.00022
83. [83]
  Raspopovic, S.; Capogrosso, M.; Petrini, F. M.; Bonizzato, M.; Rigosa, J.; Di Pino, G.; Carpaneto, J.; Controzzi, M.; Boretius, T.; Fernandez, E.; et al. Sci. Transl. Med. 2014, 6, 219r. doi: 10.1126/scitranslmed.3006820 doi: 10.1126/scitranslmed.3006820
84. [84]
  Andersen, R. A.; Hwang, E. J.; Mulliken, G. H. Annu. Rev. Psychol. 2010, 61, 169. doi: 10.1146/annurev.psych.093008.100503 doi: 10.1146/annurev.psych.093008.100503
85. [85]
  Collinger, J. L.; Wodlinger, B.; Downey, J. E.; Wang, W.; Tyler-Kabara, E. C.; Weber, D. J.; Mcmorland, A. J.; Velliste, M.; Boninger, M. L.; Schwartz, A. B. The Lancet 2013, 381, 557. doi: 10.1016/S0140-6736(12)61816-9 doi: 10.1016/S0140-6736(12)61816-9
86. [86]
  Boninger, M. L.; Collinger, J. L.; Weber, D. Brain-Computer Interfaces: Success from the University of Pittsburgh. In EDX and NM Medicine: Looking to the Future as We Address Today's Challenges, AANEM 60th Annual Meeting, San Antonio, Texas, October 2013; Kuiken, T. K., Boninger, M. L., Byrne, B. J., Eds.; 11-13.
87. [87]
  Wodlinger, B.; Downey, J. E.; Tyler-Kabara, E. C.; Schwartz, A. B.; Boninger, M. L.; Collinger, J. L. J. Neural Eng. 2015, 12, 016011. doi: 10.1088/1741-2560/12/1/016011 doi: 10.1088/1741-2560/12/1/016011
88. [88]
  Simeral, J. D.; Kim, S. -P.; Black, M. J.; Donoghue, J. P.; Hochberg, L. R. J. Neural Eng. 2010, 8, 025027. doi: 10.1088/1741-2560/8/2/025027 doi: 10.1088/1741-2560/8/2/025027
89. [89]
  Gilja, V.; Pandarinath, C.; Blabe, C. H.; Nuyujukian, P.; Simeral, J. D.; Sarma, A. A.; Sorice, B. L.; Perge, J. A.; Jarosiewicz, B.; Hochberg, L. R.; et al. Nat. Med. 2015, 21, 1142. doi: 10.1038/nm.3953 doi: 10.1038/nm.3953
90. [90]
  https://zj.zjol.com.cn/news.html?id=1366170&from=timeline&isappinstalled=0 (accessed Mar 23, 2020).
91. [91]
  Guger, C.; Allison, B.; Lebedev, M. Brain-Computer Interface Research; Springer, Cham: 2017; pp. 43-54.
92. [92]
  Branner, A.; Stein, R. B.; Fernandez, E.; Aoyagi, Y.; Normann, R. A. IEEE Trans. Biomed. Eng. 2004, 51, 146. doi: 10.1109/TBME.2003.820321 doi: 10.1109/TBME.2003.820321
93. [93]
  Wendelken, S.; Page, D. M.; Davis, T.; Wark, H. A. C.; Kluger, D. T.; Duncan, C.; Warren, D. J.; Hutchinson, D. T.; Clark, G. A. J. Neuroeng. Rehabil. 2017, 14, 121. doi: 10.1186/s12984-017-0320-4 doi: 10.1186/s12984-017-0320-4
94. [94]
  Clark, G. A.; Wendelken, S.; Page, D. M.; Davis, T.; Wark, H. A.; Normann, R. A.; Warren, D. J.; Hutchinson, D. T. Using Multiple High-Count Electrode Arrays in Human Median and Ulnar Nerves to Restore Sensorimotor Function after Previous Transradial Amputation of the Hand. In IEEE Engineering in Medicine and Biology Society Conference Proceedings, EMBC, Chicago, IL, August 26-30, 2014; IEEE: New York, 2014.
95. [95]
  Davis, T. S.; Wark, H. A. C; Hutchinson, D. T.; Warren, D. J.; Scheinblum, T.; Clark, G. A; Normann, R. A.; Greger, B. J. Neural Eng. 2016, 13, 036001. doi: 10.1088/1741-2560/13/3/036001 doi: 10.1088/1741-2560/13/3/036001
96. [96]
  Pan, J. W. Largr-scale Neural Ensemble Recording System for Rats. M. S. Dissertation, East China Normal University, Shanghai, 2008.
97. [97]
  Suner, S.; Fellows, M. R.; Vargas-Irwin, C.; Nakata, G. K.; Donoghue, J. P. IEEE Trans. Neural Syst. Rehabil. Eng. 2005, 13, 524. doi: 10.1109/TNSRE.2005.857687 doi: 10.1109/TNSRE.2005.857687
98. [98]
  Lago, N.; Cester, A. Appl. Sci.-Base. 2017, 7, 1292. doi: 10.3390/app7121292 doi: 10.3390/app7121292
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