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Citation: LI Hai-Xia, LIU Yan-Cheng, TANG Rui-Zhi, ZHANG Peng, MA Liu-Kui, WEI Chi-Yuan, WANG Wen-Feng. Reactions of Triplet-State Difloxacin with Amino Acids and dGMP: A Laser Flash Photolysis Study[J]. Acta Physico-Chimica Sinica, ;2017, 33(5): 1051-1056. doi: 10.3866/PKU.WHXB201702201 shu

Reactions of Triplet-State Difloxacin with Amino Acids and dGMP: A Laser Flash Photolysis Study

1.
Pujiang Institute, Nanjing Tech University, Nanjing 211132, P. R. China;
2.
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P. R. China

Received Date: 18 November 2016
Revised Date: 20 February 2017

Fund Project: The project was supported by the National Natural Science Foundation of China (21173252).

The reactions of triplet-state difloxacin (DFX) with various amino acids and deoxyguanylic acid in aqueous media were studied using laser flash photolysis. Tryptophan, tyrosine, cysteine, and 2'-deoxyguanosine-5'-monophosphate (dGMP) were found to completely quench the triplet state of DFX in aqueous solution, the corresponding second-order rate constants being 1.97×10⁸, 1.48×10⁸, 1.72×10⁸, and 6.92×10⁷ dm³·mol^－1·s^－1. The quenching mechanism involves electron transfer to the photoexcited triplet state of DFX from the tryptophan, tyrosine, cysteine, and dGMP moieties, followed by fast protonation of the resulting DFX anion radical.
- Laser flash photolysis,
- Difloxacin,
- Triplet state,
- Amino acid
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