Citation: LI Ni-Na, GENG Li-Na, WANG Lin, YUAN Lin-Lin, CHANG Yan-Zhong, ZHANG Jian-Jun. Determination of Iron Liposome/Water Partition Coefficients and Identification of Influencing Factors[J]. Acta Physico-Chimica Sinica, ;2015, 31(11): 2043-2048. doi: 10.3866/PKU.WHXB201509141 shu

Determination of Iron Liposome/Water Partition Coefficients and Identification of Influencing Factors

1.
1 College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024, P. R. China;
2.
2 Testing and Analysis Center, Hebei Normal University Shijiazhuang 050024, P. R. China

Corresponding author: GENG Li-Na,
Received Date: 15 May 2015
Available Online: 9 September 2015
Fund Project: 国家自然科学基金(31201305) (31201305)河北省自然科学基金-石药集团医药联合研究基金(C2012205082)资助项目 (C2012205082)

Ferric citrate liposomes (FAC-Lip) and heme liposomes (Heme-Lip) were successfully prepared by a rotary-evaporated film-ultrasonication method. The release of iron liposomes were studied in vitro, and results showed that both iron liposomes had sustained-released properties, with Heme-Lip showing superior sustained-released over FAC-Lip. The liposome/water partition coefficients (P) were determined by equilibrium dialysis and the influences on P were evaluated, as well as the binding Gibbs free energy between FAC (Heme) and liposome. The results show that P initially increased and then decreased with increasing cholesterol content and the ratio of lipid to drug. The hydrogen and electrostatic interactions were largest when P was at its maximum. At the dialysis equilibrium, the binding Gibbs free energies (ΔG) of FAC-Lip and Heme-Lip were -12.7 and -18.2 kJ·mol^-1, respectively.
- Ferric citrate,
- Heme,
- Liposome/water partition coefficient,
- Equilibrium dialysis,
- Gibbs free energy
References
1. [1]
  (1) Wei, G.; Xu, H.; Ma, Y.; Li, S. M.; Zheng, J. M. Acta Pharm. Sin. 2001, 36 (9), 707.
2. [2]
  (2) Barzanti, C.; Evans, R.; Fouquet, J.; Gouzin, L.; Howarth, N. M.; Kean, G.; Levet, E.; Wang, D.; Wayemberg, E.; Yeboah, A. A.; Kraft, A. Tetrahedron Lett. 2007, 48, 3337. doi: 10.1016/j.tetlet. 2007.03.085
3. [3]
  (3) Suo, X. B.; Li, M. L.; Wang, Y. Q.; Qiu, J. S. Chin Pharm. J. 2009, 44 (23), 1796. [索绪斌, 李慕玲, 王玉强, 裘建社. 中国药学杂志, 2009, 44 (23), 1796.]
4. [4]
  (4) Liu, K. F.; Li, X. F.; Zhang, Y. X.; Wang, F.; Wang, Y.; Deng, Y. H. Journal of Shenyang Pharmaceutical University 2010, 27 (11), 853. [刘克非, 李晓峰, 张雅昕, 王范, 王岩, 邓意辉. 沈阳药科大学学报, 2010, 27 (11), 853.]
5. [5]
  (5) Wang, Y. L.; Li, J.; Wang, R. X. Acta Phys. -Chim. Sin. 2010, 26 (7), 1742. [王艳玲, 李婕, 王任小. 物理化学学报, 2010, 26 (7), 1742.] doi: 10.3866/PKU.WHXB20100702
6. [6]
  (6) Ingram, T.; Storm, S.; Kloss, L.; Mehling, T.; Jakobtorweihen, S.; Smirnova, I. Langmuir 2013, 29, 3527. doi: 10.1021/la305035b
7. [7]
  (7) Heijden, S. A.V. D.; Jonker, M. T. O. Environ. Sci. Technol. 2009, 43, 8854. doi: 10.1021/es902278x
8. [8]
  (8) Ikonen, M.; Murtomaki, L.; Kontturi, K. J. Electroanal. Chem. 2007, 602, 189. doi: 10.1016/j.jelechem.2006.12.014
9. [9]
  (9) Esteves, F.; Moutinho, C.; Matos, C. J. Liposome Res. 2013, 23 (2), 83. doi: 10.3109/08982104.2012.742539
10. [10]
  (10) Li, Y.; Geng, L. N.; Ge, L.; Yu, P.; Duan, X. L.; Chen, J.; Chang, Y. Z. Int. J. Pharm. 2013, 454, 82. doi: 10.1016/j.ijpharm. 2013.06.078
11. [11]
  (11) Sharp, P. A. Int. J. Vitam. Nutr. Res. 2010, 80 (4-5), 231.
12. [12]
  (12) Xia, Y.; Huang, K. D.; Zhang, X. Z.; Ma, H. J. Guide of China Medicine 2013, 11 (17), 615. [夏芸, 黄坤丹, 张新征, 马海杰. 中国医药指南, 2013, 11 (17), 615.]
13. [13]
  (13) Chitra, G.; Prince, C.; Sumit, A. Food Hydrocolloids 2015, 43, 622. doi: 10.1016/j.foodhyd.2014.07.021
14. [14]
  (14) Tripathi, B.; Platel, K. Food Chemistry 2011, 126 (2), 537. doi: 10.1016/j.foodchem.2010.11.039
15. [15]
  (15) Yan, Z.; Luo, H. J. Foreign Medical Sciences (Section Hygiene) 2006, 33 (2), 90.
16. [16]
  (16) Craparo, E. F.; Bondì, M. L.; Pitarresi, G.; Cavallaro, G. CNS Neurosci. Ther. 2011, 17 (6), 670. doi: 10.1111/j.1755-5949. 2010.00199.x
17. [17]
  (17) Ma, B.; Zhang, S.; Jiang, H.; Zhao, B.; Lv, H. J. Control. Release 2007, 123 (3), 184. doi: 10.1016/j.jconrel.2007.08.022
18. [18]
  (18) Lu, Q.; Lu, P. M.; Piao, J. H.; Xu, X. L.; Chen, J.; Zhu, L.; Jiang, J. G. LWT-Food Science and Technology 2014, 57, 686. doi: 10.1016/j.lwt.2014.01.044
19. [19]
  (19) Lee, J. S.; Kim, H. W.; Chung, D.; Lee, H. G. Food Hydrocolloids 2009, 23 (8), 2226. doi: 10.1016/j.foodhyd. 2009.05.005
20. [20]
  (20) Pauletti, G. M.; Wunderli-Allenspach, H. Eur. J. Pharm. Sci. 1994, 1 (5), 273. doi: 10.1016/0928-0987(94)90022-1
21. [21]
  (21) Zhong, H. J.; Deng, Y. J.; Wang, L. J.; Du, S.; Wang, X. M.; Chen, Y. Journal of Shenyang Pharmaceutical University 2005, 22 (2), 110. [钟海军, 邓英杰, 王丽君, 杜松, 王秀敏, 陈妍. 沈阳药科大学学报, 2005, 22 (2), 110.]
22. [22]
  (22) Krä mer, S. D.; Wunderli-Allenspach, H. Pharm. Res. 1996, 13 (12), 1851. doi: 10.1023/A:1016089209798
23. [23]
  (23) Huang, C.; Mason, J. T. Proc. Natl. Acad. Sci. U. S. A. 1978, 75 (1), 308. doi: 10.1073/pnas.75.1.308
24. [24]
  (24) Wang, Z. X.; Deng, Y. J.; Zhang, X. P. Acta Pharm. Sin. 2006, 41 (4), 318. [王志轩, 邓英杰, 张晓鹏. 药学学报, 2006, 41 (4), 318.]
25. [25]
  (25) Russell, C. J.; Thorgeirsson, T. E.; Shin, Y. K. Biochemistry 1996, 35, 9526. doi: 10.1021/bi960614+
26. [26]
  (26) Dong, W. J.; Feng, J. J.; Wang, J. J. Acta Phys. -Chim. Sin. 2003, 19 (3), 230. [董文举, 冯九菊, 王键吉. 物理化学学报, 2003, 19 (3), 230.] doi: 10.3866/PKU.WHXB20030309
1. [1]
  (1) Wei, G.; Xu, H.; Ma, Y.; Li, S. M.; Zheng, J. M. Acta Pharm. Sin. 2001, 36 (9), 707.
2. [2]
  (2) Barzanti, C.; Evans, R.; Fouquet, J.; Gouzin, L.; Howarth, N. M.; Kean, G.; Levet, E.; Wang, D.; Wayemberg, E.; Yeboah, A. A.; Kraft, A. Tetrahedron Lett. 2007, 48, 3337. doi: 10.1016/j.tetlet. 2007.03.085
3. [3]
  (3) Suo, X. B.; Li, M. L.; Wang, Y. Q.; Qiu, J. S. Chin Pharm. J. 2009, 44 (23), 1796. [索绪斌, 李慕玲, 王玉强, 裘建社. 中国药学杂志, 2009, 44 (23), 1796.]
4. [4]
  (4) Liu, K. F.; Li, X. F.; Zhang, Y. X.; Wang, F.; Wang, Y.; Deng, Y. H. Journal of Shenyang Pharmaceutical University 2010, 27 (11), 853. [刘克非, 李晓峰, 张雅昕, 王范, 王岩, 邓意辉. 沈阳药科大学学报, 2010, 27 (11), 853.]
5. [5]
  (5) Wang, Y. L.; Li, J.; Wang, R. X. Acta Phys. -Chim. Sin. 2010, 26 (7), 1742. [王艳玲, 李婕, 王任小. 物理化学学报, 2010, 26 (7), 1742.] doi: 10.3866/PKU.WHXB20100702
6. [6]
  (6) Ingram, T.; Storm, S.; Kloss, L.; Mehling, T.; Jakobtorweihen, S.; Smirnova, I. Langmuir 2013, 29, 3527. doi: 10.1021/la305035b
7. [7]
  (7) Heijden, S. A.V. D.; Jonker, M. T. O. Environ. Sci. Technol. 2009, 43, 8854. doi: 10.1021/es902278x
8. [8]
  (8) Ikonen, M.; Murtomaki, L.; Kontturi, K. J. Electroanal. Chem. 2007, 602, 189. doi: 10.1016/j.jelechem.2006.12.014
9. [9]
  (9) Esteves, F.; Moutinho, C.; Matos, C. J. Liposome Res. 2013, 23 (2), 83. doi: 10.3109/08982104.2012.742539
10. [10]
  (10) Li, Y.; Geng, L. N.; Ge, L.; Yu, P.; Duan, X. L.; Chen, J.; Chang, Y. Z. Int. J. Pharm. 2013, 454, 82. doi: 10.1016/j.ijpharm. 2013.06.078
11. [11]
  (11) Sharp, P. A. Int. J. Vitam. Nutr. Res. 2010, 80 (4-5), 231.
12. [12]
  (12) Xia, Y.; Huang, K. D.; Zhang, X. Z.; Ma, H. J. Guide of China Medicine 2013, 11 (17), 615. [夏芸, 黄坤丹, 张新征, 马海杰. 中国医药指南, 2013, 11 (17), 615.]
13. [13]
  (13) Chitra, G.; Prince, C.; Sumit, A. Food Hydrocolloids 2015, 43, 622. doi: 10.1016/j.foodhyd.2014.07.021
14. [14]
  (14) Tripathi, B.; Platel, K. Food Chemistry 2011, 126 (2), 537. doi: 10.1016/j.foodchem.2010.11.039
15. [15]
  (15) Yan, Z.; Luo, H. J. Foreign Medical Sciences (Section Hygiene) 2006, 33 (2), 90.
16. [16]
  (16) Craparo, E. F.; Bondì, M. L.; Pitarresi, G.; Cavallaro, G. CNS Neurosci. Ther. 2011, 17 (6), 670. doi: 10.1111/j.1755-5949. 2010.00199.x
17. [17]
  (17) Ma, B.; Zhang, S.; Jiang, H.; Zhao, B.; Lv, H. J. Control. Release 2007, 123 (3), 184. doi: 10.1016/j.jconrel.2007.08.022
18. [18]
  (18) Lu, Q.; Lu, P. M.; Piao, J. H.; Xu, X. L.; Chen, J.; Zhu, L.; Jiang, J. G. LWT-Food Science and Technology 2014, 57, 686. doi: 10.1016/j.lwt.2014.01.044
19. [19]
  (19) Lee, J. S.; Kim, H. W.; Chung, D.; Lee, H. G. Food Hydrocolloids 2009, 23 (8), 2226. doi: 10.1016/j.foodhyd. 2009.05.005
20. [20]
  (20) Pauletti, G. M.; Wunderli-Allenspach, H. Eur. J. Pharm. Sci. 1994, 1 (5), 273. doi: 10.1016/0928-0987(94)90022-1
21. [21]
  (21) Zhong, H. J.; Deng, Y. J.; Wang, L. J.; Du, S.; Wang, X. M.; Chen, Y. Journal of Shenyang Pharmaceutical University 2005, 22 (2), 110. [钟海军, 邓英杰, 王丽君, 杜松, 王秀敏, 陈妍. 沈阳药科大学学报, 2005, 22 (2), 110.]
22. [22]
  (22) Krä mer, S. D.; Wunderli-Allenspach, H. Pharm. Res. 1996, 13 (12), 1851. doi: 10.1023/A:1016089209798
23. [23]
  (23) Huang, C.; Mason, J. T. Proc. Natl. Acad. Sci. U. S. A. 1978, 75 (1), 308. doi: 10.1073/pnas.75.1.308
24. [24]
  (24) Wang, Z. X.; Deng, Y. J.; Zhang, X. P. Acta Pharm. Sin. 2006, 41 (4), 318. [王志轩, 邓英杰, 张晓鹏. 药学学报, 2006, 41 (4), 318.]
25. [25]
  (25) Russell, C. J.; Thorgeirsson, T. E.; Shin, Y. K. Biochemistry 1996, 35, 9526. doi: 10.1021/bi960614+
26. [26]
  (26) Dong, W. J.; Feng, J. J.; Wang, J. J. Acta Phys. -Chim. Sin. 2003, 19 (3), 230. [董文举, 冯九菊, 王键吉. 物理化学学报, 2003, 19 (3), 230.] doi: 10.3866/PKU.WHXB20030309
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沈阳化工大学材料科学与工程学院沈阳 110142

Determination of Iron Liposome/Water Partition Coefficients and Identification of Influencing Factors

References

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通讯作者: 陈斌, bchen63@163.com