Citation: ZHANG Xin-Zhuang, XIAO Wei, XU Xiao-Jie, WANG Zhen-Zhong, CAO Ling, SUN Lan. Study on Mechanism of the Reduning Injection on the Influenza Virus Using Network Pharmacology Method[J]. Acta Physico-Chimica Sinica, ;2013, 29(07): 1415-1420. doi: 10.3866/PKU.WHXB201304171 shu

Study on Mechanism of the Reduning Injection on the Influenza Virus Using Network Pharmacology Method

1.
1 College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, P. R. China;
2 National Key Laboratory of Pharmaceutical New Technology for Chinese Medicine, Kanion Pharmaceutical Corporation, Lianyungang 222002, Jiangsu Province, P. R. China;
3 College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China

Received Date: 22 February 2013
Available Online: 17 April 2013
Fund Project: 项目(2011ZX09304)资助 (2011ZX09304)

The mechanisms of the Reduning injection on the influenza virus were studied by computer methods at the molecular level, including docking and network analysis. A neuraminidase (NA) activity assay was used to verify the predicted results in vitro. Results show that most of the compounds in the Reduning injection exhibit od drug-like properties. The mechanism of the Reduning injection may be that it affects viral entry, RNA synthesis, or viral release, which limits influenza virus replication. Potential active molecules of the Reduning injection were found by analyzing the network parameters of compound-target interaction networks. The experimental results suggest that of the potential active molecules, luteolin displayed significant inhibitory activity toward the influenza A virus, while quercetin proved less effective, which supports the predicted results.
- Network pharmacology,
- Reduning,
- Influenza virus,
- Traditional Chinese medicine,
- Neuraminidase
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