Citation: RUB Malik Abdul, NAQVI Andleeb Z.. Effect of Inorganic Salts and Ureas on the Micellization Behavior of Antidepressant Drug Imipramine Hydrochloride at Various Concentrations and Temperatures[J]. Acta Physico-Chimica Sinica, ;2012, 28(04): 885-891. doi: 10.3866/PKU.WHXB201202202 shu

Effect of Inorganic Salts and Ureas on the Micellization Behavior of Antidepressant Drug Imipramine Hydrochloride at Various Concentrations and Temperatures

1.
Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India

Received Date: 30 November 2011
Available Online: 20 February 2012
Fund Project: The project was supported by the Council of Scientific and Industrial Research, New Delhi, India (01 (2208)/08/EMR-II). (01 (2208)/08/EMR-II)

In the present study we report the micellization behavior of imipramine hydrochloride (IMP) in absence and presence of different concentrations of inorganic salts (LiCl, NaF, NaCl, NaBr, and KCl) and ureas (urea and thiourea) over the temperature range from 288.15 to 303.15 K. The critical micellization concentrations (cmc) of drug and drug+additive systems were determined by conductometric technique. With increasing temperature the cmc first increases then decreases. Maximum cmc values were obtained at 293.15 K with or without additives. In presence of inorganic salts the cmc value decreases which is explained on the basis of nature and ion size of the added ion. Urea and thiourea also decrease the cmc at low concentrations (0.2 mmol·L^-1 urea and 0.1 mmol·L^-1 thiourea), but, at higher concentrations, increase in cmc is observed. The related thermodynamic parameters are also evaluated and discussed.
- Antidepressant drug,
- Imipramine hydrochloride,
- Critical micelle concentration,
- Conductivity,
- Inorganic salt
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