Citation: WANG Qing, CHU Yan-Qiu, ZHANG Kai, DAI Xin-Hua, FANG Xiang, DING Chuan-Fan. Effect of Alkali Metal Ions on the Dissociation of Glycine Pentapeptide in the Gas Phase[J]. Acta Physico-Chimica Sinica, ;2012, 28(04): 971-977. doi: 10.3866/PKU.WHXB201112201
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To obtain more structural information of polypeptides, glycine pentapeptide (simplified as GGGGG or G5) was chosen as a model to investigate the impact of alkali metal ions on the dissociation of GGGGG in the gas phase. Stoichiometric G5 and alkali metal salt solutions, including Li + , Na+ , K+ , Rb+ , were mixed, respectively, and then the solutions were left to stand at room temperature for 10 h to reach equilibrium. The mass spectrometric results indicated that the alkali metal ions and G5 could form 1:1 or 2: 1 non-covalent complexes in solution. The energy of the collision induced dissociation (CID) was 25 eV. The gas phase CID results demonstrate that in the 1:1 complexes, the extent of fragmentation decreases according to the order: Li+, Na+, K+, Rb+. Moreover, the unusual c, z ions were observed in the Rb+ complex. In the 2:1 non-covalent complexes, the extent of fragmentation increases according to the order: Li+ , Na+ , K+, Rb+. The gas phase dissociation of the Na+, K+, Rb+ 2:1 complexes are easier than their 1:1 complexes. Except for Li + , the activation abilities of the double metal ions to G5 are stronger than that of the single metal ion to G5, which can induce more dissection sites in the glycine pentapeptide and lead to the formation of more kinds of fragment ions.
-
-
[1]
(1) Hughes, M. N. The Inorganic Chemistry of Biological Processes, 2nd ed;Wiley: New York, 1972; pp 89-124, 257-295.
-
[2]
(2) Gress, R. P.; Gross, M. L. J. Am. Chem. Soc. 1990, 112, 5098.
-
[3]
(3) Jia,W. T.; Lu, H. J.; Yun, D.; Yang, P. Y. Acta Chim. Sin. 2008, 65 (3), 177. [贾韦韬, 陆豪杰, 贠栋, 杨芃原. 化学学报, 2008, 65 (3), 177.]
-
[4]
(4) Chu, Y. Q.; Dai, X. H.; Jiang, D.; Fang, X.; Ding, C. F. Rapid Commun. Mass Spectrom. 2010, 24, 2255.
-
[5]
(5) Dai, X. H.; Chu, Y. Q.; Jiang, D.; He, X. D.; Fang, X.; Ding, C. F. Chin. J. Anal. Chem. 2010, 38 (12), 1747. [戴新华, 储艳秋, 姜丹, 何小丹, 方向, 丁传凡. 分析化学, 2010, 38 (12), 1747.]
-
[6]
(6) Li, P.; Liu, B. Y.;Wang, H. L.; Li, A. L.;Wang, H. X. Chin. J. Anal. Chem. 2007, 35 (1), 87. [李萍, 刘炳玉, 王鸿丽, 李爱玲, 王红霞. 分析化学, 2007, 35 (1), 87.]
-
[7]
(7) Yu, C. T.; Guo, Y. L. Acta Chim. Sin. 2001, 59 (4), 615. [余翀天, 郭寅龙. 化学学报, 2001, 59 (4), 615.]
-
[8]
(8) Biemann, K. Methods Enzymol. 1990, 193, 455.
- [9]
-
[10]
(10) Papayannopoulos, I. A. Mass Spectrom. Rev. 1995, 14, 49.
-
[11]
(11) Dai, Z. Y.; Chu, Y. Q.;Wu, B.;Wu, L.; Ding, C. F. Acta Pharmcol. Sin. 2008, 29 (6), 759.
-
[12]
(12) He, X. D.; Jiang, D.; Chen, C.; Chu, Y. Q.; Ding, C. F. Acta Phys. -Chim. Sin. 2010, 26 (10), 2604. [何小丹, 姜丹, 陈琛, 储艳秋, 丁传凡. 物理化学学报, 2010, 26 (10), 2604.]
-
[13]
(13) Zhang, E.; Zu, L. L.; Fang,W. H.; Huang, L. Y.; He, D. C. Chem. J. Chin. Univ. 2008, 29 (6), 1185. [张娥, 祖莉莉, 方维海, 黄凌云, 何大澄. 高等学校化学学报, 2008, 29 (6), 1185.]
-
[14]
(14) Nair, H.; Somogyi, A.;Wysocki, V. H. J. Mass Spectrom. 1996, 31, 1141.
-
[15]
(15) Dongre, A. R.; Jones, J. L.; Somogyi, A.;Wysocki, V. H. J. Am. Chem. Soc. 1996, 118, 8365.
-
[16]
(16) Wysocki, V. H.; Tsaprailis, G.; Smith, L. L.; Breci, L. A. J. Mass Spectrom. 2000, 35, 1399.
-
[17]
(17) Huang, Y.; Triscari, J. M.; Pasa-Tolic, L.; Anderson, G. A.; Lipton, M. S.; Smith, R. D.;Wysocki, V. H. J. Am. Chem. Soc. 2004, 126, 3034.
-
[18]
(18) Tsaprailis, G.; Nair, H.; Zhong,W.; Kuppannan, K.; Futrell, J. H.;Wysocki, V. H. Anal. Chem. 2004, 76, 2083.
-
[19]
(19) Mallis, L.; Russell, M. D. H. Anal. Chem. 1988, 60, 2299.
-
[20]
(20) Leary, J. A.; Zhou, Z. G.; Ogden, S. A.;Williams, T. D. J. Am. Soc. Mass Spectrom. 1990, 1, 473.
-
[21]
(21) Teesch, L. M.; Orlando, R. C.; Adams, J. J. Am. Chem. Soc. 1991, 113, 3668.
-
[22]
(22) Wang, J. Y.; Siu, K.W. M.; Guevremont, R. J. Mass Spectrom. 1996, 31, 159.
-
[23]
(23) Hu, P. F.; Gross, M. L. J. Am. Chem. Soc. 1993, 115, 8821.
-
[24]
(24) Farrugia, J. M.; O'Hair, A. R. J. Int. J. Mass Spectrom. 2003, 222, 229.
-
[25]
(25) Pingitore, F.;Wesdemiotis, C. Anal. Chem. 2005, 77, 1796.
-
[26]
(26) Grese, R. P.; Cerny, R. L.; Gross, M. L. J. Am. Chem. Soc. 1989, 111, 2835.
-
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