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Citation: KHAN Abbul Bashar, NAQVI Andleeb Z.. Micellization Behavior of an Amphiphilic Drug Promethazine Hydrochloride-Surfactant System in an Aqueous Medium[J]. Acta Physico-Chimica Sinica, ;2011, 27(08): 1900-1906. doi: 10.3866/PKU.WHXB20110817 shu

Micellization Behavior of an Amphiphilic Drug Promethazine Hydrochloride-Surfactant System in an Aqueous Medium

1.
Department of Chemistry, Aligarh Muslim University, Aligarh-202002, India

Received Date: 22 March 2011
Available Online: 20 June 2011
Fund Project: The project was supported by Department of Science and Technology's Science and Engineering Research Council Scheme of India (SR/FTP/CS-49/2007) for NAQVI Andleeb Z. and fellowship of University Grant Commission of India for KHAN Abbul Bashar. (SR/FTP/CS-49/2007)

The behavior of the mixed amphiphilic drug promethazine hydrochloride (PMT) and cationic as well as nonionic surfactants was studied by tensiometry. The cmc values of the PMT-surfactant systems decrease at a surfactant mole fraction of 0.1 and it then becomes constant. The critical micelle concentration (cmc) values are lower than the ideal cmc (cmc^*) values for PMT/TX-100, PMT/TX-114, PMT/Tween 20, and PMT/Tween 60 systems. For the PMT/Tween 40, PMT/Tween 80, PMT/CPC, and PMT/CPB systems the cmc values are close to the cmc* values. This indicates that PMT forms mixed micelles with these surfactants by attractive interactions. The surface excess (Γ_max) decreases in the presence of surfactants. The rigid structure of the drug makes adsorption easier and the contribution of the surfactant at the interface decreases. The interaction parameters β^m (for the mixed micelles) and β^σ (for the mixed monolayer) are negative indicating attraction among the mixed components.
- Promethazine hydrochloride,
- Cationic surfactant,
- Nonionic surfactant,
- Interaction parameter
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