Citation: CAO Yun-Zhu, WEI Dong-Ming, REN Dong-Xue, CHEN Chen, XING Yong-Heng, SHI Zhan. Design, Synthesis and Mimic Catalytic Activity of a Vanadium Haloperoxidase Conformation Model Molecule[J]. Acta Physico-Chimica Sinica, ;2011, 27(03): 539-546. doi: 10.3866/PKU.WHXB20110326 shu

Design, Synthesis and Mimic Catalytic Activity of a Vanadium Haloperoxidase Conformation Model Molecule

1.
1. College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, Liaoning Province, P. R. China;
2. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China

Received Date: 20 October 2010
Available Online: 16 February 2011
Fund Project: 国家自然科学基金(21071071) (21071071) 大连市教育基金(2009J21DW004) (2009J21DW004)吉林大学无机合成与制备化学国家重点实验室(2010-15)资助 (2010-15)

Based on mimicing the N, O coordination environment of the active center of vanadium haloperoxidase (V-HPOs) and the hydrogen-bond interaction between the active center and amino acid residues or water molecules, we designed and synthesized two kinds of oxidovanadium complexes: (C₃H₅N₂)₂[(VO)₂(μ₂-C₂O₄)(C₂O₄)₂(H₂O)₂] (1) and (VO₂)₂(μ₂- C₂O₄)(C₂H₄N₂)₂ (2). We determined their structures by X-ray single crystal diffraction. The crystal structure analysis indicated that the coordination environments of those oxidovanadium complexes were similar to the active center of vanadium haloperoxidase, and there seemed to be a mimicing α-helix structure in the three-dimensional packing structure of the complexes. Additionally, by studying the bromination reaction activity we found that the oxidovanadium complexes had an upper activity during the mimic catalytic process.
- Vanadium haloperoxidase,
- Oxidovanadium complex,
- Crystal structure,
- α-Helix,
- Molecule conformation
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