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Citation: JIANG He, WANG Jin-Bo, XIONG Wei, JIA Yun, QIN Rui-Xiang, LIU De-Rong, CHEN Hua. Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by RuCl₂[(S)-P-Phos]-[(S)-DAIPEN][J]. Acta Physico-Chimica Sinica, ;2010, 26(03): 675-678. doi: 10.3866/PKU.WHXB20100225 shu

Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by RuCl₂[(S)-P-Phos]-[(S)-DAIPEN]

1.
College of Chemistry &Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, P. R. China; Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China

Received Date: 4 September 2009
Available Online: 29 December 2009

A ruthenium phosphine diamine complex RuCl2[(S)-P-Phos]-[(S)-DAIPEN] [P-Phos: 2,2',6,6'-tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine, DAIPEN: 1,1'-di(4-anisyl)-2-iopropyl-1,2-ethylenediamine] for the asymmetric hydrogenation of aromatic ketones has been studied. The influences of different bases , (CH3)3COK concentration, organic solvent, and molar ratio of substrate to catalyst on activity and enantioselectivity were investigated. Under the following optimum conditions: n(ketone):n(KOH):n(catalyst)=1000:20:1, pH2=2 MPa and T=30 ℃, the conversion of acetophenone and the enantioselectivity (ee) of S-1-phenylethanol was 100% and 88.5%, respectively. Additionally, the ee value of 2'-bromophenyl ethanol was 97.1%.
- Asymmetric hydrogenation,
- Ruthenium-phosphine complex,
- Chiral diamine,
- Aromatic ketones
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沈阳化工大学材料科学与工程学院沈阳 110142

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Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by RuCl2[(S)-P-Phos]-[(S)-DAIPEN]

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通讯作者: 陈斌, bchen63@163.com

Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by RuCl₂[(S)-P-Phos]-[(S)-DAIPEN]