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Citation: YAN Hua, YANG Jian-Guo, LIANG Hua-Ding, PAN Fu-You, ZHAO Song-Lin, LI Jing-Jing. Interaction between Cinnamic Acid and Bovine Serum Albumin and the Influence of Alcohol[J]. Acta Physico-Chimica Sinica, ;2008, 24(03): 543-546. doi: 10.3866/PKU.WHXB20080334 shu

Interaction between Cinnamic Acid and Bovine Serum Albumin and the Influence of Alcohol

1.
School of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, Zhejiang Province, P. R. China; Office of Assets Administration, Taizhou University, Linhai 317000, Zhejiang Province, P. R. China

Received Date: 3 August 2007
Available Online: 4 December 2007

The interaction between cinnamic acid and bovine serumalbumin (BSA) has been studied with fluorimeter under physiological conditions. The experimental results demonstrated that the combination reaction of cinnamic acid and BSA was a static quenching process because of forming 1:1 complex, and the dominant binding force was hydrophobic interaction. At 310 K, the binding constant and the number of binding sites were 3.07×104 L·mol-1 and 1.10, respectively. And the conformation of BSA was changed due to the presence of cinnamic acid. Furthermore, the binding constant and the number of binding sites would decrease due to adding alcohol.
- Cinnamic acid; Bovine serumalbumin; Alcohol; Fluorescence spectrum; Interaction
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