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Citation: JI Te, ZHAO Hong-Wei, ZHANG Zeng-Yan, GE Min, WANG Wen-Feng, YU Xiao-Han, XU Hong-Jie. Terahertz Time-Domain Spectroscopy of D-, L-, and DL- Penicillamines[J]. Acta Physico-Chimica Sinica, ;2006, 22(09): 1159-1162. doi: 10.3866/PKU.WHXB20060925 shu

Terahertz Time-Domain Spectroscopy of D-, L-, and DL- Penicillamines

1.
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P. R. China

Received Date: 14 February 2006
Available Online: 4 September 2006

Far-infrared absorption spectra of D-, L-, and DL- penicillamines have been measured by terahertz time-domain spectroscopy (THz-TDS) in the frequency range from 0.2 THz to 1.8 THz. The experimental results show large difference among absorption spectra of enantiomers (D- and L- penicillamines) and their racemic compound (DL-penicillamine), which probably originated from the difference of crystal structure and vibration modes of crystal lattice. The study indicates that THz-TDS can be used for discrimination of D-, L-, and DL- penicillamines. The absorption spectra of their mixtures have been fitted by the absorption spectra of D- and L- penicillamines, and we have demonstrated the feasibility of this method to determine quantitatively the mixture ratios of penicillamine enantiomers. These will not only give a new experimental method to distinguish chiral medicine, but also provide a suggestion for further comprehending the interaction of chiral medicine and target biomolecule.
- THz-TDS;D-, L-, and DL- penicillamines;Enantiomers;Quantitative analysis
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