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Citation: Sha Yin-Lin, Li Yin-Ling, Qiu Yang, Wang Qi, Lai Lu-Hua, Tang You-Qi. de novo Design and Conformational Studies of a β-hairpin Forming Peptide[J]. Acta Physico-Chimica Sinica, ;2002, 18(10): 907-910. doi: 10.3866/PKU.WHXB20021008 shu

de novo Design and Conformational Studies of a β-hairpin Forming Peptide

1.
Single Molecule and Nano-biomedicine Laboratory, Department of Biophysics, School of Basic Medical Sciences, Peking University, Beijing　100083;Institute of Physical Chemistry, Peking University, Beijing　100871

Received Date: 25 February 2002
Available Online: 15 October 2002

A 12-residue peptide (R1G2T3F4W5V6d-P7S8V9N10Y11F12, β2) with cross-strand amino acid pairs V6V9, F4Y11 and Y3F12, predicted to form β-hairpin, was designed and synthesized by Fmoc/But strategy. The circular dichroism spectrum ofβ2 in PBS buffer shows a maximum at about 202 nm and a minimum at about 217.5 nm, a typical β-hairpin characteristics that have been postulated as the common contribution from a β-turn mixed with a β-sheet. The FT-IR experiments confirmed the secondary structural contents of β2.
- de novo design;β-hairpin;β-turn;β-sheet;Cross-strand amino acid pairs;CD;FT-IR
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