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Citation: Dai Jian-Bo, Bai Ling-Jun, Zhang Yi-Bao, Zang Ya-Ru, Jiang Dong-Qing, Gu Zhuo-Ying, Zhao Xue-Zhuang. Research on the Oxidation of Adrenaline——Kinetics and Mechanism of the Oxidation Reaction and the Radical Intermidate[J]. Acta Physico-Chimica Sinica, ;1991, 7(03): 260-269. doi: 10.3866/PKU.WHXB19910302 shu

Research on the Oxidation of Adrenaline——Kinetics and Mechanism of the Oxidation Reaction and the Radical Intermidate

1.
Department of Chemistry and the Central Laboratory, Nankai University, Tianjin 300071

Received Date: 11 November 1989
Available Online: 15 June 1991

Using the UV absorption spectrometry in connection with computer simulation, the oxidation reaction kinetics of adrenaline forming adrenoehrome, with H_2O_2 in Cu(Ⅱ) existing as a catalyst had been studied. Since there is some overlap in the spectra of adrenaline and adrenochrome (Fig.1), the double wave-length method was used. The order of this reaction with respect to adrenaline is 1/2. The corresponding apparent reaction rate constants are independent of the initial concentration [Adin]_0 of adrenline (Table 1), but depend on the concentration of Cu(II), H_2O_2 and H~+ in accordance with equations (1~a) and (1~b). The experimental values kE and regression calculated values kC of the apparent rate constants k(app) under different experimental conditions are listed in the last two rows of Table 2, respectively. The linear correlation of kE and kC is shown in Fig.2. Examining this figure, it can be said that the regression calculated values are satisfiable.
In order to propose a reasonable probable mechanism of this reaction, by means of the electron paramagnetic resonance method, the radical intermidate was examined under the flow condition or sometimes a radical stabilizer...
- Adrenaline; Radical intermidate; Kinetics; Mechanism of oxidation reaction
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