Citation: Ting Zhao, Panpan Li, Xu Wang. Comprehensive Chemical Experiment of Macroscopic Non-Equilibrium Supramolecular Self-Assembly[J]. University Chemistry, ;2024, 39(1): 126-133. doi: 10.3866/PKU.DXHX202305057 shu

Comprehensive Chemical Experiment of Macroscopic Non-Equilibrium Supramolecular Self-Assembly

National Engineering Research Center for Colloidal Materials, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China

Corresponding author: Xu Wang, wangxu@sdu.edu.cn
Received Date: 17 May 2023

In order to enable undergraduate students majoring in chemistry and related fields to understand the basic characteristics of hydrogel materials and their applications in macroscopic non-equilibrium supramolecular self-assembly, we have introduced a comprehensive research-oriented experiment titled "Macroscopic Non-equilibrium Supramolecular Self-Assembly Experiment". This experiment mainly includes the preparation method of polyelectrolyte hydrogels based on homogeneous free radical polymerization, the construction method of macroscopic non-equilibrium supramolecular self-assembly system based on urea-urease timing reaction, characterization of assembly performance, and exploration of the mechanisms of non-equilibrium assembly and disassembly. Through the practice of this experiment, students can deepen their understanding of supramolecular interactions, master the preparation and characterization methods of relevant polymer hydrogels, as well as consolidate the use of some commonly used instruments. By combining teaching and practice, we establish a bridge between teaching and scientific research to broaden students' scientific perspectives, stimulate their research interests, and cultivate students' innovative abilities and scientific thinking.
- Supramolecular interactions,
- Non-equilibrium assembly,
- Polyelectrolyte hydrogels,
- Urease,
- Comprehensive chemical experiment
1. [1]
  Das, K.; Gabrielli, L.; Prins, L. J. Angew. Chem. Int. Ed. 2021, 60, 20120.
2. [2]
  Zhao, T.; E, Y.; Cui, J.; Hao, J.; Wang, X. J. Colloid Interface Sci. 2022, 623, 674.
3. [3]
  Li, P.; Song, A.; Hao, J.; Wang, X. Soft Matter 2022, 18, 3856.
4. [4]
5. [5]
  van Rossum, S. A. P.; Tena-Solsona, M.; van Esch, J. H.; Eelkema, R.; Boekhoven, J. Chem. Soc. Rev. 2017, 46, 5519.
6. [6]
  Xie, X.; Zhang, Y.; Liang, Y.; Wang, M.; Cui, Y.; Li, J.; Liu, C. Angew. Chem. Int. Ed. 2021, 61, 202114471.
7. [7]
8. [8]
  Wang, Y.; Oldenhof, S.; Versluis, F.; Shah, M.; Zhang, K.; van Steijn, V.; Guo, X.; Eelkema, R.; van Esch, J. H. Small 2019, 15, 1804154.
9. [9]
  Ghosh, A.; Paul, I.; Schmittel, M. J. Am. Chem. Soc. 2021, 143, 5319.
10. [10]
  Bradley, M.; Lazim, A. M.; Eastoe, J. Polymers 2011, 3, 1036.
11. [11]
  Li, X.; Wang, G.; Zhang, Q.; Liu, Y.; Sun, T.; Liu, S. J. Colloid Interface Sci. 2022, 615, 732.
12. [12]
  Pappas, C. G.; Sasselli, I.R.; Ulijn, R. V. Angew. Chem. Int. Ed. 2015, 54, 8119.
13. [13]
  Guo, J.; Zhang, H. Y.; Zhou, Y.; Liu, Y. Chem. Commun. 2017, 53, 6089.
14. [14]
  Schwarz, P. S.; Tebcharani, L.; Heger, J. E.; Müller-Buschbaum, P.; Boekhoven, J. Chem. Sci. 2021, 12, 9969.
15. [15]
  Zhong, Y.; Li, P.; Hao, J.; Wang, X. ACS Appl. Mater. Interfaces 2020, 12, 6471.
16. [16]
  Loget, G.; Kuhn, A. Nat. Commun. 2011, 2, 535.
17. [17]
  Sekine, T.; Kakuta, T.; Nakamura, T.; Kobayashi, Y.; Takashima, Y.; Harada, A. Sci. Rep. 2014, 4, 6348.
18. [18]
  Nakahata, M.; Takashima, Y.; Yamaguchi, H.; Harada, A. Nat. Commun. 2011, 2, 511.
19. [19]
  Li, J.; Xu, Z.; Xiao, Y.; Gao, G.; Chen, J.; Yin, J.; Fu, J. J. Mater. Chem. B 2018, 6, 257.
20. [20]
  Ju, G.; Guo, F.; Zhang, Q.; Kuehne, A. J. C.; Cui, S.; Cheng, M.; Shi, F. Adv. Mater. 2017, 29, 1702444.
21. [21]
22. [22]
  Li, J.; Xu, Z.; Xiao, Y.; Gao, G.; Chen, J.; Yin, J.; Fu, J. J. Mater. Chem. B 2018, 6, 257.
23. [23]
  Dogu, S.; Kilic, M.; Okay, O. J. Appl. Polym. Sci. 2009, 113, 1375.
24. [24]
  Che, H.; Cao, S.; van Hest, J. C. M. J. Am. Chem. Soc. 2018, 140, 5356.
1. [1]
  Zhongrui Wang , Yuwen Meng , Xu Wang . 双层水凝胶的制备及其pH响应变形实验. University Chemistry, 2025, 40(8): 255-264. doi: 10.12461/PKU.DXHX202410038
2. [2]
  Ling Zhang , Jing Kang . Turn Waste into Valuable: Preparation of High-Strength Water-Based Adhesives from Polymethylmethacrylate Wastes: a Comprehensive Chemical Experiments. University Chemistry, 2024, 39(2): 221-226. doi: 10.3866/PKU.DXHX202306075
3. [3]
  Yang Li , Jiachen Li , Daidi Fan . 二硫化钼纳米片的制备及其纳米酶性能探究——介绍一个大学化学综合实验. University Chemistry, 2025, 40(8): 233-240. doi: 10.12461/PKU.DXHX202410016
4. [4]
  Yan Yu , Zijian Wang , Hong Wu , Wei Hu . The Mystery of Self-Healing Materials: Breaking the Mirror and Restoring It. University Chemistry, 2026, 41(2): 268-272. doi: 10.12461/PKU.DXHX202501011
5. [5]
  Hongyun Liu , Jiarun Li , Xinyi Li , Zhe Liu , Jiaxuan Li , Cong Xiao . Course Ideological and Political Design of a Comprehensive Chemistry Experiment: Constructing a Visual Molecular Logic System Based on Intelligent Hydrogel Film Electrodes. University Chemistry, 2024, 39(2): 227-233. doi: 10.3866/PKU.DXHX202309070
6. [6]
  Tao Jiang , Yuting Wang , Lüjin Gao , Yi Zou , Bowen Zhu , Li Chen , Xianzeng Li . Experimental Design for the Preparation of Composite Solid Electrolytes for Application in All-Solid-State Batteries: Exploration of Comprehensive Chemistry Laboratory Teaching. University Chemistry, 2024, 39(2): 371-378. doi: 10.3866/PKU.DXHX202308057
7. [7]
  Huiying Xu , Minghui Liang , Zhi Zhou , Hui Gao , Wei Yi . Application of Quantum Chemistry Computation and Visual Analysis in Teaching of Weak Interactions. University Chemistry, 2025, 40(3): 199-205. doi: 10.12461/PKU.DXHX202407011
8. [8]
  Zhaoxuan ZHU , Lixin WANG , Xiaoning TANG , Long LI , Yan SHI , Jiaojing SHAO . Application of poly(vinyl alcohol) conductive hydrogel electrolytes in zinc ion batteries. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 893-902. doi: 10.11862/CJIC.20240368
9. [9]
  Ke Qiu , Fengmei Wang , Mochou Liao , Kerun Zhu , Jiawei Chen , Wei Zhang , Yongyao Xia , Xiaoli Dong , Fei Wang . A Fumed SiO₂-based Composite Hydrogel Polymer Electrolyte for Near-Neutral Zinc-Air Batteries. Acta Physico-Chimica Sinica, 2024, 40(3): 2304036-0. doi: 10.3866/PKU.WHXB202304036
10. [10]
  Feng Zheng , Ruxun Yuan , Xiaogang Wang . “Research-Oriented” Comprehensive Experimental Design in Polymer Chemistry: the Case of Polyimide Aerogels. University Chemistry, 2024, 39(10): 210-218. doi: 10.12461/PKU.DXHX202404027
11. [11]
  Yan Zhang , Xiaoyan Cao , Yiming Li , Shuwei Xia , Mutai Bao . Comparison of Electrolyte Solutions Section in Physical Chemistry Textbooks at Home and Abroad. University Chemistry, 2025, 40(9): 303-309. doi: 10.12461/PKU.DXHX202502027
12. [12]
  Jiaxun Wu , Mingde Li , Li Dang . The R eaction of Metal Selenium Complexes with Olefins as a Tutorial Case Study for Analyzing Molecular Orbital Interaction Modes. University Chemistry, 2025, 40(3): 108-115. doi: 10.12461/PKU.DXHX202405098
13. [13]
  Jianan Fang , Youhao Gu , Zexuan Gui , Laiying Zhang , Jiawei Yan , Ruming Yuan , Xiaoming Xu . Experimental Improvement and Expansion of the Electromotive Force Method to Determine the Mean Activity Coefficient of Electrolyte Solution. University Chemistry, 2025, 40(11): 263-271. doi: 10.12461/PKU.DXHX202504055
14. [14]
  Changsheng An , Tao Liu . Decoding SEI chemistry at the lithium-metal potential. Acta Physico-Chimica Sinica, 2025, 41(9): 100101-0. doi: 10.1016/j.actphy.2025.100101
15. [15]
  Lijuan Liu , Xionglei Wang . Preparation of Hydrogels from Waste Thermosetting Unsaturated Polyester Resin by Controllable Catalytic Degradation: A Comprehensive Chemical Experiment. University Chemistry, 2024, 39(11): 313-318. doi: 10.12461/PKU.DXHX202403060
16. [16]
  Haoxiang Zhang , Zhihan Zhao , Yongchen Jin , Zhiqiang Niu , Jinlei Tian . Synthesis of an Efficient Absorbent Gel: A Recommended Comprehensive Chemistry Experiment. University Chemistry, 2024, 39(11): 251-258. doi: 10.12461/PKU.DXHX202401084
17. [17]
  Sen Lin , Rong Jiang , Xuefeng Lu , Guohui Jiang , Kaining Ding , Jinshui Zhang , Xinchen Wang . Promoting the Integration of Science and Education through Digital Intelligence Technology: Data-Driven Development of Efficient Water Electrolysis Catalysts in Comprehensive Chemical Experiment Teaching. University Chemistry, 2026, 41(1): 188-203. doi: 10.12461/PKU.DXHX202505090
18. [18]
  Wenxu Liu , Feng Han , Boxuan Wang , Huayi Liu , Xiaobin Gu , Xin Zhang , Yao Liu . Comprehensive Chemical Experiment: Design, Synthesis, and Photoelectronic Properties Study of Fully Non-Fused Ring Electron Acceptors. University Chemistry, 2025, 40(10): 263-275. doi: 10.12461/PKU.DXHX202412021
19. [19]
  Yuxin CHEN , Yanni LING , Yuqing YAO , Keyi WANG , Linna LI , Xin ZHANG , Qin WANG , Hongdao LI , Wenmin WANG . Construction, structures, and interaction with DNA of two Sm^Ⅲ₄ complexes. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1141-1150. doi: 10.11862/CJIC.20240258
20. [20]
  Dan LUO , Xingcheng LIU , Dong LI , Tong CHANG . Metal-support interaction effects on CO activation over Co_n/SiO₂ catalysts. Chinese Journal of Inorganic Chemistry, 2025, 41(11): 2337-2344. doi: 10.11862/CJIC.20250003

Get Citation

PDF

XML

Metrics

PDF Downloads(6)
Abstract views(1912)
HTML views(190)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142