Citation: Wenhao Lin, Ming Liu, Maoxia Yang, Jiayi Zhang, Chenghui Wang, Xin Xiao. Application of Supramolecular Chemistry in Undergraduate Laboratory: A New Method for Separation of Aminophenol Isomers by Cucurbit[6]uril[J]. University Chemistry, ;2023, 38(4): 260-268. doi: 10.3866/PKU.DXHX202210088 shu

Application of Supramolecular Chemistry in Undergraduate Laboratory: A New Method for Separation of Aminophenol Isomers by Cucurbit[6]uril

Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, China

Received Date: 27 October 2022

Based on the research-oriented laboratory teaching concept of “thick foundation, wide professional, and comprehensive”, this paper combines the theoretical knowledge of supramolecular chemistry and macrocyclic chemistry to design a new comprehensive experiment of selective gradient separation of o-, m-, p-aminophenol isomers with the purity of 91.46%, 94.16% and 96.70%, respectively, based on supramolecular self-assembly using cucurbit[6]uril as the host. All reagents can be recycled after the experiment, fully embodying the concept of green chemistry. This experiment involves TLC, LC, IR, and other important analytical methods to monitor the separation process, purity analysis, and structural characterization of the target product, which enables students to fully master basic theoretical knowledge, experimental principles, and learn to analyze experimental phenomena, thereby improving students’ research-oriented literacy and ability to comprehensively apply knowledge.
- Cucurbit[n]uril,
- Aminophenol,
- Isomeride,
- Separation method,
- Comprehensive experiment
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