Home

Citation: Xuanhe Zhang, Xiaowu Jiang, Enming Hu, Jing Cheng, Xueping Yang, Jian Jin. Continuous-Flow Approach towards the Preparation of Triphenylmethanol[J]. University Chemistry, ;2023, 38(9): 172-178. doi: 10.3866/PKU.DXHX202210077 shu

Continuous-Flow Approach towards the Preparation of Triphenylmethanol

1.
School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, Guangdong Province, China;
2.
Education Center of Experiments and Innovations, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, Guangdong Province, China

Corresponding author: Jian Jin, jianjin@hit.edu.cn
Received Date: 26 October 2022

The preparation of triphenylmethanol is a classic teaching experiment in the field of chemistry and serves as an important combination of organic chemistry theory and practical laboratory skills. However, the experiment has a low success rate due to the complexity of the apparatus, difficulties in handling Grignard reagents, and the strict requirements for anhydrous and oxygen-free conditions. Moreover, repeated solvent transfers result in solvent exposure for both teachers and students. In this study, we designed and constructed a continuous flow apparatus for the preparation of Grignard reagents using a medium-pressure syringe pump and a fixed-bed continuous flow reactor, achieving the continuous production of triphenylmethanol. The continuous flow apparatus for Grignard reagent preparation is simple to assemble, completely eliminates organic solvent exposure for teachers and students, and exhibits good reproducibility in the conversion of bromobenzene to Grignard reagent. Within this continuous flow setup, the preparation of Grignard reagents is stable, controllable, and safe. Excess magnesium turnings do not require quenching and can be reused.
- Preparation of triphenylmethanol,
- Grignard reagent,
- Continuous flow
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
1. [1]
  Wanmin Cheng , Juan Du , Peiwen Liu , Yiyun Jiang , Hong Jiang . Photoinitiated Grignard Reagent Synthesis and Experimental Improvement in Triphenylmethanol Preparation. University Chemistry, 2024, 39(5): 238-242. doi: 10.3866/PKU.DXHX202311066
2. [2]
  Haoqi Zhang , Borui Yao , Yun Zhang , Zhiguang Song , Bo Wang . 通过格氏试剂与环氧苯乙烯的反应认识其组成与性质的复杂性. University Chemistry, 2026, 41(5): 50-61. doi: 10.12461/PKU.DXHX202511129
3. [3]
  Feng Han , Fuxian Wan , Ying Li , Congcong Zhang , Yuanhong Zhang , Chengxia Miao . Comprehensive Organic Chemistry Experiment: Phosphotungstic Acid-Catalyzed Direct Conversion of Triphenylmethanol for the Synthesis of Oxime Ethers. University Chemistry, 2025, 40(3): 342-348. doi: 10.12461/PKU.DXHX202405181
4. [4]
  Ling Liu , Haibin Wang , Genrong Qiang . Curriculum Ideological and Political Design for the Comprehensive Preparation Experiment of Ethyl Benzoate Synthesized from Benzyl Alcohol. University Chemistry, 2024, 39(2): 94-98. doi: 10.3866/PKU.DXHX202304080
5. [5]
  Tao Wen , Tao Zhang , Changguo Sun , Jinyu Liu . Preparation of Dess-Martin Reagent and Its Application in Oxidizing Cyclohexanol. University Chemistry, 2024, 39(5): 20-26. doi: 10.3866/PKU.DXHX202309055
6. [6]
  Zitong Chen , Zipei Su , Jiangfeng Qian . Aromatic Alkali Metal Reagents: Structures, Properties and Applications. University Chemistry, 2024, 39(8): 149-162. doi: 10.3866/PKU.DXHX202311054
7. [7]
  Yuahua Weng , Chanzi Ruan , Xiaohang Qiu , Yiru Wang , Juanjuan Song , Yongxian Fan , Dongcheng Liu , Yanping Ren , Xiuqiong Zeng , Faqiong Zhao , Mei Shi , Min Hu , Wan Li , Xiuyun Wang , Wenwei Zhang , Weihong Li , Yong Fan , Jianrong Zhang , Shuyong Zhang . Specifications, Storage, and Suggestions on Handling of Chemical Reagents. University Chemistry, 2026, 41(3): 67-76. doi: 10.12461/PKU.DXHX202507040
8. [8]
  Jian Jin , Jing Cheng , Xueping Yang . Integration Practice of Organic Chemistry Experiment and Safety Education: Taking the Synthesis of Triphenylmethanol as an Example. University Chemistry, 2024, 39(3): 345-350. doi: 10.3866/PKU.DXHX202309010
9. [9]
  Zihao Guo , Shichen Ma , Kin Shing Chan . 烯烃环化反应中6电子试剂的等瓣相似性和等电子关系. University Chemistry, 2025, 40(6): 160-166. doi: 10.12461/PKU.DXHX202408038
10. [10]
  Xiaoyang Li , Xiaowei Huang , Yimeng Zhang , Huan Liu , Shao Jin , Junpeng Zhuang . Comprehensive Chemical Experiments on the Synthesis of 1,3-Dibromo-5,5-Dimethylhydantoin and Its Application as a Brominating Reagent. University Chemistry, 2025, 40(7): 286-293. doi: 10.12461/PKU.DXHX202408035
11. [11]
  Yinuo Wang , Yichen Gan , Keyu Li , Dazhen Xu . Synthesis of 2-(4-Chlorobenzylidene) malononitrile via a self-made continuous flow reactor: a proposed comprehensive chemistry experiment. University Chemistry, 2026, 41(7): 319-325. doi: 10.12461/PKU.DXHX202506036
12. [12]
  Chenxu Gong , Weizhen Wang , Ruiying Zhang , Wenfeng Wang , Yuanming Li , Yaofeng Yuan , Keyin Ye . Computational Chemistry-Assisted Organic Structure Analysis (CCAOSA): A Case Study of Propeller-Shaped Hexabenzotriphenylene. University Chemistry, 2026, 41(4): 438-446. doi: 10.12461/PKU.DXHX202503076
13. [13]
  Xin Feng , Kexin Guo , Chunguang Jia , Bowen Liu , Suqin Ci , Junxiang Chen , Zhenhai Wen . Hydrogen Generation Coupling with High-Selectivity Electrocatalytic Glycerol Valorization into Formate in an Acid-Alkali Dual-Electrolyte Flow Electrolyzer. Acta Physico-Chimica Sinica, 2024, 40(5): 2303050-0. doi: 10.3866/PKU.WHXB202303050
14. [14]
  Xiaochuang Di , Mushan Yuan , Junyu Lu , Shenquan Yang , Cuiqing Zhou , Yang Chen , Huawei Zou . Navigating the continuous parameter space for ultra-broadband microwave absorption: a sequence-aware deep learning and evolutionary optimization approach. Acta Physico-Chimica Sinica, 2026, 42(9): 100270-0. doi: 10.1016/j.actphy.2026.100270
15. [15]
  Minna Ma , Yujin Ouyang , Yuan Wu , Mingwei Yuan , Lijuan Yang . Green Synthesis of Medical Chemiluminescence Reagents by Photocatalytic Oxidation. University Chemistry, 2024, 39(5): 134-143. doi: 10.3866/PKU.DXHX202310093
16. [16]
  Zhuo WANG , Xiaotong LI , Zhipeng HU , Junqiao PAN . Three-dimensional porous carbon decorated with nano bismuth particles: Preparation and sodium storage properties. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 267-274. doi: 10.11862/CJIC.20240223
17. [17]
  Shuting KONG , Fengshi ZHANG , Zhiyi LU , Yanling LIU , Minglang YE , Zhengfang HU , Longsheng WANG , Bing HU , Haiying WANG . Research advance of the preparation of tributyl citrate catalyzed by supported heteropolyacid catalysts. Chinese Journal of Inorganic Chemistry, 2026, 42(3): 441-452. doi: 10.11862/CJIC.20250303
18. [18]
  Xi Tan , Chunhong Chen , Lijia Leng , Yulong Zhang . 二苯甲烷制备实验改进研究与拓展. University Chemistry, 2026, 41(5): 159-169. doi: 10.12461/PKU.DXHX202511049
19. [19]
  Bin Liu . Teaching case design of chemistry “101 Plan” syntheticchemistry experiment course: taking the experiment of preparation of platinum nanocatalyst supported on carbon and determination of its electrochemical catalytic performance of methanol oxidation as an example. University Chemistry, 2026, 41(6): 125-135. doi: 10.12461/PKU.DXHX202506043
20. [20]
  Guodong Xu , Chengcai Sheng , Xiaomeng Zhao , Tuojiang Zhang , Zongtang Liu , Jun Dong . Reform of Comprehensive Organic Chemistry Experiments in the Context of Emerging Engineering Education: A Case Study on the Improved Preparation of Benzocaine. University Chemistry, 2024, 39(11): 286-295. doi: 10.12461/PKU.DXHX202403094

Get Citation

PDF

XML

Metrics

PDF Downloads(4)
Abstract views(2261)
HTML views(183)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return