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Citation: ZHENG Yuan, LAN Quan, ZHA Zhenggen. An Exploration of the Design-Oriented Experiments: The Retrosynthetic Analysis, Design and Preparation of Cinnamic Acid[J]. University Chemistry, ;2019, 34(6): 53-59. doi: 10.3866/PKU.DXHX201811009 shu

An Exploration of the Design-Oriented Experiments: The Retrosynthetic Analysis, Design and Preparation of Cinnamic Acid

Demonstration Center for Experimental Chemistry Education(University of Science and Technology of China), Hefei 230026, P. R. China

Received Date: 12 November 2018

This article focuses on the synthesis of cinnamic acid. Retrosynthetic analysis and synthetic design have shown that the construction of cinnamic acid can be achieved by several protocols, including the aqueous Heck reaction, the solvent-free Perkin reaction, the aqueous Wittig reaction and the aqueous Knoevenagel reaction. These protocols extend the synthetic design thinking of students. These experiments cover the synthesis, purification and characterization of cinnamic acid, helping students understand and complete a basis scientific research process; thus, students' comprehensive ability is improved.
- Heck reaction,
- Perkin reaction,
- Wittig reaction,
- Knoevenagel reaction,
- Cinnamic acid,
- Designing experiment,
- Retrosynthesis analysis
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