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Citation: WANG Zhipeng, CHENG Nong-Yi, LIANG Yan-Yu, MA Xin-Yu. Brief Introduction of Structures and Discovery of Novel Lysine Post-Translational Modifications in Native Proteins[J]. University Chemistry, ;2017, 32(12): 41-47. doi: 10.3866/PKU.DXHX201708002 shu

Brief Introduction of Structures and Discovery of Novel Lysine Post-Translational Modifications in Native Proteins

1.
Chemistry Department, Texas A & M University, College Station, TX 77840, USA;
2.
Chemistry Department, Tsinghua University, Beijing 100084, P. R. China;
3.
Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA

An increasing amount of novel protein lysine post-translational modifications (PTMs) have been gradually discovered. These PTMs with a large structural diversity widely exist in human proteome, which play an important epigenetically regulatory function to the chromatin structure and gene expression. This manuscript will briefly summarize the discovery and structure properties of the lysine PTMs from a chemical point of view, which will further benefit to teaching and research.
- Lysine,
- Post-translational modification,
- Proteome
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