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Citation: WANG Yunxia, ZHAO Yu, WANG Lanying, LI Jianli. Preparation of 5-Methoxy-2-Phenyl-2,3-Dihydrobenzofuran: A Comprehensive College Chemistry Experiment[J]. University Chemistry, ;2018, 33(1): 69-72. doi: 10.3866/PKU.DXHX201707014 shu

Preparation of 5-Methoxy-2-Phenyl-2,3-Dihydrobenzofuran: A Comprehensive College Chemistry Experiment

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, P. R. China

Received Date: 12 July 2017

A new comprehensive college chemistry experiment was introduced. 5-Methoxy-2-phenyl-2,3-dihydrobenzofuran was prepared from 4-methoxyphenol and styrene by using 1,1,1,3,3,3-hexafluoropropan-2-ol as the solvent and 2,3-dichloro-5,6-dicyanobenzoquinone as the oxidant at room temperature. The structure was identified by IR, ¹H NMR, ¹³C NMR and HRMS. In the experiment, students' research interest and exploring spirit will be stimulated, the skill of comprehensive experiment operation and analysis will be improved, and furthermore, the innovative thinking and scientific research ability will be cultivated.
- 5-Methoxy-2-phenyl-2,3-dihydrobenzofuran,
- 4-Methoxy-phenol,
- Styrene
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
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