Citation: LIU Xiaomin, XU Xiuli, NIE Xuemei, GUO Wei, ZHANG Feng. Research progress on the fragmentation mechanisms of mass spectrometry soft ionization and screening of chemical hazardous substances in food[J]. Chinese Journal of Chromatography, ;2020, 38(7): 750-758. doi: 10.3724/SP.J.1123.2020.03002 shu

Research progress on the fragmentation mechanisms of mass spectrometry soft ionization and screening of chemical hazardous substances in food

LIU Xiaomin ^1,2 ,
XU Xiuli ¹ ,
NIE Xuemei ¹ ,
GUO Wei ¹ ,
ZHANG Feng ^1,,

1.
Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China;
2.
China Medical University, Shenyang 110122, China

Corresponding author: ZHANG Feng, fengzhang@126.com
Received Date: 1 March 2020

Fund Project: National Key Research and Development Program (No. 2018YFC1602403)

Hazardous chemicals in food are an important cause of food safety problems. Mass spectrometry is an effective tool for the qualitative and quantitative analysis of these substances. In this paper, the fragmentation mechanisms for several chemical hazardous substances, including pesticides, veterinary drugs, mycotoxins, and other chemical pollutants classified by structural analogs, are reviewed. For each class of compounds, we summarize the characteristic fragments and neutral loss generated by cleavage in the mass spectrometry analysis. We also summarize the mechanisms applied to screen and discover new structural analogs in food. This review can help researchers analyze and confirm the structure of compounds and provide a theoretical basis for the discovery of new structural analogs in food.
- fragmentation mechanisms,
- soft ionization technique,
- mass spectrometry,
- characteristic fragments,
- untargeted screening,
- unknown compounds,
- review
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