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Citation: GONG Li, KANG Jingwu. Drug target deconvolution by chemical proteomics[J]. Chinese Journal of Chromatography, ;2020, 38(8): 877-879. doi: 10.3724/SP.J.1123.2019.12014 shu

Drug target deconvolution by chemical proteomics

GONG Li ^1,2 ,
KANG Jingwu ^1,2,,

1.
State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China

Corresponding author: KANG Jingwu, jingwu.kang@sioc.ac.cn
Received Date: 25 December 2019

Fund Project: National Natural Science Foundation of China (Nos. 21775158, 21375140)

Drug target identification can help establish the association between drug activity and phenotypes, elucidate the mechanism of action, discover off-target effects and drug resistance mechanisms, discover new targets for therapeutic drugs, and predict possible side effects and toxicity at an early stage of drug discovery, thereby reducing the risk of failure in drug development. Although rapid progress has been made in scientific discoveries and technological advancements, the identification of drug targets is still a daunting task. Herein, the research progress in drug target identification during the past decade, especially novel technologies without chemical labeling, have been reviewed.
- drug target identification,
- chemical proteomics,
- review
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