Citation: SHI Yiwei, ZHANG Ning, CAO Wen, HONG Zhanying. Advances in dispersive liquid-liquid microextraction and its application to analysis of biological samples[J]. Chinese Journal of Chromatography, ;2020, 38(5): 491-501. doi: 10.3724/SP.J.1123.2019.10026 shu

Advances in dispersive liquid-liquid microextraction and its application to analysis of biological samples

Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai Key Laboratory for Pharmaceutical(Chinese Materia Medica) Metabolites Research, Shanghai 200433, China

Corresponding author: HONG Zhanying, hongzhy001@163.com
Received Date: 24 October 2019

Fund Project: National Natural Science Foundation of China (Nos. 81673386, 81872829).

Dispersive liquid-liquid microextraction (DLLME) is a mini-extraction technology with merits of low cost, environment friendliness, and high extraction efficiency; moreover, this method is easy to operate and requires only a short operation time. In this paper, several extraction models, including normal dispersive liquid-liquid microextraction, ionic liquid dispersive liquid-liquid microextraction, and ultrasound-assisted dispersive liquid-liquid microextraction, are reviewed according to the type of extraction solvents and dispersive methods. This paper also summarizes the application of DLLME to the analysis of biological samples in the last five years.
- dispersive liquid-liquid microextraction (DLLME),
- extraction solvents,
- dispersive methods,
- biological samples,
- review
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