Citation: LÜ Ying, ZHOU Zhigang, CHEN Si, ZHANG Xiaojun. Progress on the metabolic rules and detection methods for okadaic acid related toxins in biological samples[J]. Chinese Journal of Chromatography, ;2020, 38(6): 621-626. doi: 10.3724/SP.J.1123.2019.10016 shu

Progress on the metabolic rules and detection methods for okadaic acid related toxins in biological samples

LÜ Ying ^1,2 ,
ZHOU Zhigang ³ ,
CHEN Si ^2,4,, ,
ZHANG Xiaojun ^2,4

1.
School of Fisheries of Zhejiang Ocean University, Zhoushan 316022, China;
2.
Laboratory of Aquatic Product Processing and Quality Safety, Marine Fisheries Research Institute of Zhejiang Province, Zhoushan 316021, China;
3.
Zhoushan Police Evidence Identification Center, Zhoushan 316021, China;
4.
Key Laboratory of Sustainable Utilization of Technology Research for Fisheries Resources of Zhejiang Province, Scientific Observing and Experimental Station of Fishery Resources for Key Fishing Grounds, Ministry of Agriculture, Zhoushan 316021, China

Corresponding author: CHEN Si, sichen_ns@163.com
Received Date: 16 October 2019

Fund Project: Science and Technology Program of Zhoushan (No. 2017C32073).

In recent years, red tide pollution in China has become increasingly serious, leading to a number of shellfish poisoning cases, thereby posing a threat to human health and safety. Okadaic acid (OA) and its analogs (dinophysistoxins, DTXs) are the most widely distributed diarrhetic shellfish poisons, which result in acute diarrheal toxicity and various types of chronic toxicity. It is imperative to establish a method for determination of OA related toxin residues in biological fluid samples, so that accurate diagnosis of poisoning in patients is possible. The present paper briefly introduced the main physicochemical properties, poisoning incidents, toxicological effects for the toxins, also summarized recent progress on the metabolic rules and detection methods for OA related toxins in biological samples.
- liquid chromatography-tandem mass spectrometry (LC-MS/MS),
- in vivo metabolism,
- okadaic acid (OA),
- biological samples,
- review
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