Citation: SONG Shiyao, BAI Yu, LIU Huwei. Advances in the development of the sample preparation techniques in lipidomics[J]. Chinese Journal of Chromatography, ;2020, 38(1): 66-73. doi: 10.3724/SP.J.1123.2019.07011 shu

Advances in the development of the sample preparation techniques in lipidomics

Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

Corresponding author: BAI Yu, yu.bai@pku.edu.cn
Received Date: 8 July 2019

Fund Project: National Natural Science Foundation of China (Nos. 21527809, 21775008, 21575007).

Lipids play an important physiological role in living system. They are the major components of cellular membranes, in addition to participating in energy storage as well as signal recognition and transmission. In recent years, an increasing number of studies have shown that disturbances in lipid metabolism are closely related to the development of some diseases. Lipid analysis is of great significance for understanding the mechanism and the process of diseases. Because of the matrix interference and low concentration of analytes, existing techniques require sample preparation steps to ensure good analytical performance. In the present study, sample preparation methods in lipidomics used in various fields are reviewed, including lipid extraction methods, such as liquid-liquid extraction and solid phase extraction, as well as the chemical derivatization techniques for different lipid categories. In addition, the development of the sample preparation in lipidomics is also prospected.
- lipidomics,
- sample preparation,
- lipid extraction,
- chemical derivatization,
- review
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