Citation: FENG Mengyu, LIU Shuan, GAO Yan, ZHOU Shukun, GUO Zhen, LI Xiuqin, ZHANG Qinghe. Qualitative identification of impurities and principal component quantitative analysis of zearalanone on purity certified reference material[J]. Chinese Journal of Chromatography, ;2019, 37(8): 911-917. doi: 10.3724/SP.J.1123.2019.04028 shu

Qualitative identification of impurities and principal component quantitative analysis of zearalanone on purity certified reference material

FENG Mengyu ^1, ,
LIU Shuan ^1,2 ,
GAO Yan ¹ ,
ZHOU Shukun ¹ ,
GUO Zhen ¹ ,
LI Xiuqin ¹ ,
ZHANG Qinghe ¹

1.
National Institute of Metrology, Beijing 100029, China;
2.
Beijing University of Chemical Technology, Beijing 100029, China

Received Date: 15 April 2019

Fund Project: National Key Research and Development Program of China "Strategic Key Program for International Science and Technology Innovation Cooperation Projects" (No. 2016YFE0206500).

A liquid chromatography method was established for the determination of zearalanone (ZAN) raw material. The qualitative analysis of ZAN and its trace impurities was performed by ultra performance liquid chromatography-diode array detector (UPLC-DAD) and ultra performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS), and the response factors of each impurity were calculated. The three main organic impurities in the ZAN raw material were identified as β -zearalanol, α -zearalanol and a dehydration product of zearalanol with relative response factors of 0.5352, 0.8594 and 0.6973, respectively. The main component of the ZAN raw material was determined by the calibration factor normalization method. The purity of zearalanone was determined to be 99.6% with a standard deviation of 0.01%. This method can provide a technical support for the development of ZAN standard materials.
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