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Citation: ZHOU Xiujin, YANG Huicheng, ZHANG Jing, SHAO Honghong, LENG Xiangyang, HAN Chao. Immunomodulatory effect of low relative molecular mass seleno-aminopolysaccharide in Acanthopagrus schlegelii by hepatic metabolomics analysis[J]. Chinese Journal of Chromatography, ;2019, 37(9): 939-945. doi: 10.3724/SP.J.1123.2019.03002 shu

Immunomodulatory effect of low relative molecular mass seleno-aminopolysaccharide in Acanthopagrus schlegelii by hepatic metabolomics analysis

1.
Comprehensive Technical Service Center of Zhoushan Customs, Zhoushan 316000, China;
2.
Zhejiang Marine Development Research Institute, Zhoushan 316000, China;
3.
SCIEX Company, Shanghai 200335, China;
4.
College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China

Received Date: 5 March 2019

Fund Project: International Science and Technology Cooperation Program of China (No. 2015DFA30980).

To investigate the immunomodulatory mechanism of low relative molecular mass seleno-aminopolysaccharide, a metabolomics method based on liquid chromatography-time-of-flight mass spectrometry (LC-TOF-MS) was used to analyze the endogenous metabolites changes in the liver of Acanthopagrus schlegelii. The potential biomarkers were screened using non-targeted mass spectrometry with the XCMS^plus software, and the related metabolic pathways were analyzed using MetaboAnalyst3.0 website. The results showed that the liver metabolites in the low relative molecular mass seleno-aminopolysaccharide-fed group were significantly different from those in the blank group. Also, 32 biomarkers were identified. Additionally, low relative molecular mass seleno-aminopolysaccharide could enhance the immune function of Acathopagrus schlegelii via amino acid, nucleotide, and nitrogen metabolism, aminoacyl-transfer ribonucleic acid (tRNA) biosynthesis, and other metabolic pathways. This study therefore provides a scientific basis for elucidating the immunoenhancement mechanism of low relative molecular mass seleno-aminopolysaccharide.
- high-definition mass spectrometry,
- metabolomics,
- low relative molecular mass seleno-aminopolysaccharide,
- Acanthopagrus schlegelii,
- immunomodulatory
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