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Citation: HU Shengjie, LI You, ZHOU Ying, YI Xionghai, DENG Xiaojun, CHEN Qin, XU Dunming, NIU Bing. Determination of 50 non-edible additives in health food using the QuEChERS method and liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2019, 37(7): 701-711. doi: 10.3724/SP.J.1123.2019.01046 shu

Determination of 50 non-edible additives in health food using the QuEChERS method and liquid chromatography-tandem mass spectrometry

HU Shengjie ^1, ,
LI You ² ,
ZHOU Ying ³ ,
YI Xionghai ² ,
DENG Xiaojun ² ,
CHEN Qin ¹ ,
XU Dunming ⁴ ,
NIU Bing ¹

1.
Department of Food Engineering, School of Life Science, Shanghai University, Shanghai 200444, China;
2.
Animal, Plant and Food Inspection & Quarantine Center, Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200135, China;
3.
Sanda University, Shanghai 201209, China;
4.
Inspection and Quarantine Technology Center, Xiamen Entry-Exit Inspection and Quarantine Bureau, Xiamen 361012, China

Received Date: 26 January 2019

Fund Project: National Key Research and Development Plan Project (Nos. 2017YFF0211003, 2018YFC1603603)

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established for the determination of 50 non-food additives in health food. The samples were extracted with methanol and purified using the QuEChERS method. The separation was performed on an Agilent Phoroshell SB C₁₈ column (150 mm×3.0 mm, 2.7 μm) with a mobile phase of 0.1% (v/v) formic acid aqueous solution and acetonitrile. The determination was performed by MS/MS in positive or negative electrospray ionization and multiple reaction monitoring mode. The results demonstrated that all 50 compounds could be well separated with a good linear relationship (r²>0.99). The limits of detection (LODs, S/N ≥ 3) and limits of quantification (LOQs, S/N ≥ 10) were in the range of 0.010-1 mg/kg and 0.020-2 mg/kg, respectively. The matrix effects in five kinds of typical health foods (oral liquid, tablets, ointments, pills, and capsules) were evaluated and reduced by means of matrix matching. At the spiked levels of 1 LOQ, 2 LOQ, and 10 LOQ, the recoveries of all drugs varied from 63.1% to 115.7% with relative standard deviations (RSDs) of no more than 8.9% (n=6). The method is simple, sensitive, practical, and suitable for monitoring 50 non-edible additives in health food.
- liquid chromatography-tandem mass spectrometry (LC-MS/MS),
- QuEChERS,
- non-edible additives,
- health food
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