Citation: CHEN Xi, WU Ci, WANG Longxiang, WANG Yue, NING Xingshuang, XU Chuanpeng, LI Wang, CHU Yingqian. High-throughput screening and quantitative analysis method of 112 pharmaceutical and personal care products in water based on ultra-high performance liquid chromatography with high-resolution mass spectrometry[J]. Chinese Journal of Chromatography, ;2018, 36(11): 1147-1157. doi: 10.3724/SP.J.1123.2018.06029 shu

High-throughput screening and quantitative analysis method of 112 pharmaceutical and personal care products in water based on ultra-high performance liquid chromatography with high-resolution mass spectrometry

1.
Dayaowan Customs of the People's Republic of China, Dalian 116600, China;
2.
Zhuanghe Customs of the People's Republic of China, Zhuanghe 116400, China

Received Date: 26 June 2018

Fund Project: Science and Technology Project of Liaoning Entry-Exit Inspection and Quarantine Bureau (No. LK14-2016)

An effective method based on ultra-high performance liquid chromatography-triple quadrupole/electrostatic field orbitrap mass spectrometry (UHPLC-Q-Orbitrap MS) was developed for high-throughput screening and quantitative analysis of 112 pharmaceutical and personal care products (PPCPs) in water. The water samples were separately extracted under alkaline and acidic conditions and cleaned on an SPE column (Cleanert PEP-2). The sample was separated and detected by UHPLC-Q-Orbitrap MS, and the data were collected in full MS scan/date dependent MS2 mode. All the 112 PPCPs in water were qualitatively screened and quantified on the basis of the peak area of the precursor ion. The PPCPs showed a good linear response in the mass concentration range of three orders of magnitude (r² ≥ 0.9901), and the limits of quantification were between 0.002 μg/L and 0.8 μg/L. The recoveries of 60.1%-129.5% were achieved at different spiked levels of 0.2, 0.4, and 0.8 μg/L, and the RSDs were 1.1%-17.8% (n=6). Moreover, the method was used to screen the PPCPs in water samples acquired from seven regions of Dalian city (China), and 16 PPCPs were identified and quantified. Therefore, this simple method with high sensitivity and wide screening range can be applied to water quality management and environmental risk monitoring.
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沈阳化工大学材料科学与工程学院沈阳 110142