Citation: GONG Jian, LIN Canyuan, XIONG Xiaoping, CHEN Diyun, CHEN Yongheng, WU Cuiqin. Simultaneous determination of 28 corticosteroids in surface water by ultra-high performance liquid chromatography-electrospray tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2018, 36(11): 1158-1166. doi: 10.3724/SP.J.1123.2018.06010 shu

Simultaneous determination of 28 corticosteroids in surface water by ultra-high performance liquid chromatography-electrospray tandem mass spectrometry

School of Environmental Science and Engineering, Guangzhou University, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, Guangzhou 510006, China

Received Date: 14 June 2018

Fund Project: National Natural Science Foundation of China (No. 41673110)

A comprehensive analytical method was developed for simultaneous determination of 28 corticosteroids in surface water based on ultra-high performance liquid chromatography- electrospray tandem mass spectrometry (UHPLC-ESI-MS/MS). The solid-phase extraction was performed using hydrophilic-lipophilic balance (HLB) cartridges, and the chromatographic separation was achieved on a reversed-phase C8 column. Qualitative and quantitative analyses were performed in the dynamic multiple reaction monitoring (DMRM) mode using positive and negative electrospray ionization (ESI±). The 28 target compounds were quantified by the internal standard method. Good linear relationships were obtained (R²>0.99) for the 28 analytes in the concentration range of 1.0-100 μg/L. The method limits of detection and quantification were in the range of 0.21-0.48 ng/L and 0.32-0.72 ng/L, respectively. When the matrix spiking levels were at 5.0, 10, and 50 ng/L, the average recoveries for the target compounds ranged from 68.6% to 108.7%, and the relative standard deviations (RSDs) were between 0.1% and 8.1%. Because of its high sensitivity, good precision, and reliability, this method can be widely applied to trace monitoring of glucocorticoids and mineral ocorticoids for investigating their behaviors and risks of corticosteroids in the environment.
- ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS),
- corticosteroids,
- surface water
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