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Citation: SHAO Meiqi, CHEN Yan, PENG Qing, LIU Pengfu, WU Jiequn, CHU Xiaohe. Determination of aminobutanol by high performance liquid chromatography based on charge transfer reaction[J]. Chinese Journal of Chromatography, ;2018, 36(8): 817-821. doi: 10.3724/SP.J.1123.2018.03026 shu

Determination of aminobutanol by high performance liquid chromatography based on charge transfer reaction

SHAO Meiqi ^1, ,
CHEN Yan ¹ ,
PENG Qing ¹ ,
LIU Pengfu ^1,2 ,
WU Jiequn ^1,2 ,
CHU Xiaohe ^1,2

1.
Zhejiang University of Technology, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Hangzhou 310014, China;
2.
Zhejiang Yangtze Delta Region Pharmaceutical Technology Research Park, Deqing 313200, China

Received Date: 26 March 2018

A method was developed for the determination of the content of aminobutanol by high performance liquid chromatography (HPLC) based on charge transfer reaction. Under the condition of a borax-boric acid buffer solution of pH 8.4, aminobutanol and tetra-chloro-benzoquinone reacted at 60℃ for 60 min, and were analyzed by an HPLC-ultraviolet detector. The charge-transfer complex was separated on an Agilent Extend C18 column (250 mm×4.6 mm, 5 μm) with 0.001% (v/v) triethylamine and methanol as the mobile phases for gradient elution at a flow rate of 1 mL/min. The limit of quantification of aminobutanol was 0.01 g/L, the linear range was 0.1-0.6 g/L, and the correlation coefficient (R²) was 0.9994. The spiked recoveries of the method were 98.3%-103.6% with relative standard deviations (RSDs) of 0.9%-1.6%. The method is simple and quick, and suitable for the rapid detection of aminobutanol.
- high performance liquid chromatography (HPLC),
- charge transfer reaction,
- aminobutanol,
- tetra-chloro-benzoquinone (TCBQ)
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