Citation: ZHAO Sihan, WANG Zhengmeng, DENG Hongxia, DUAN Jiahui, WANG Jinyi, LIU Shuhui. Determination of total phthalates in perfume and their exposure assessment[J]. Chinese Journal of Chromatography, ;2017, 35(12): 1301-1305. doi: 10.3724/SP.J.1123.2017.08026 shu

Determination of total phthalates in perfume and their exposure assessment

College of Chemistry and Pharmacy, Northwest A & F University, Yangling 712100, China

Received Date: 30 August 2017

A novel method for rapid screening of phthalates (PAEs) in perfumes was developed. The PAEs were hydrolyzed to phthalic acid (PA), and the PA in the acidified solution was extracted with tributyl phosphate (TBP) which was detected by high performance liquid chromatography-diode array detection (HPLC-DAD). Meanwhile exposure dose to PAEs was estimated by the percentage of a topically applied dose that permeates the skin. The parameters such as the concentration and volume of KOH, the volume of ethanol, hydrolysis time and temperature were employed to evaluate the hydrolysis efficiency of PAEs. The optimized hydrolysis conditions were 10 mL of 4 mol/L KOH, and 1 mL of ethanol at 80℃ for 20 min. The linear range of phthalic acid was 3-240 μmol/L with a good correlation coefficient (R²=0.9991). The limits of detection (LOD) and quantification (LOQ) were 4.6 μmol/kg and 5.9 μmol/kg, respectively. The recoveries varied from 83.4% to 92.7% with relative standard deviations equal to or lower than 6.8%(n=5). A total of 35 perfume samples were determined, and the contents of total PAEs were found in the range of
- high performance liquid chromatography (HPLC),
- phthalates (PAEs),
- perfumes,
- hydrolysis,
- exposure dose
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沈阳化工大学材料科学与工程学院沈阳 110142