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Citation: LUO Lixin, ZHAO Xinghua, JIANG Minjie, ZHANG Haiyan, WANG Yu. Preparation of filter paper with chiral separation function by oxidation and Schiff-base reaction[J]. Chinese Journal of Chromatography, ;2017, 35(9): 912-917. doi: 10.3724/SP.J.1123.2017.04020 shu

Preparation of filter paper with chiral separation function by oxidation and Schiff-base reaction

College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China

Received Date: 9 April 2017

Fund Project: 2013 Hubei Province Small and Medium-Sized Enterprises (SME) Technology Innovation Project (No. 201319).

Paper chromatography (PC) is a highly flexible, fast, and efficient separation method. In this study, a chromatographic paper with a chiral separation function was investigated and a paper chromatographic method for chiral separation was developed. Single-factor experiments and orthogonal tests were used to determine the optimal oxidation conditions for filter paper. The optimal conditions were that sodium periodate 4% (mass percentage), pH 2 buffer solution, reaction temperature 45℃, and reaction time 4 h. Under the optimal conditions, the aldehyde group content of a dialdehyde-based filter paper was 57.93% (amount of substance percentage). A paper-based chiral separation material was synthesized by a microwave-assisted Schiff-base reaction of the oxidized filter paper with L-glutamic acid. The developing solvent for separating racemic tartaric acid using this chiral filter paper consisted of 100 mL of n-butanol, 50 mL of 50%(v/v) acetic acid, and 0.1000 g of bromophenol blue. The rate of flow (R_f) values of L-tartaric acid and D-tartaric acid were 0.52 and 0.40, respectively. This method does not require large-scale equipment to perform the chiral separation and it is therefore suitable for general teaching, research, and industrial applications.
- paper chromatography (PC),
- chiral separation,
- dialdehyde filter paper (DaFP),
- chiral separation filter paper (CFP),
- Schiff-base reaction
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