Home

Citation: LI Liangxing, LAI Caiyun, ZHENG Aini, WU Hongxing, SU Caoyin, GAO Chongkai, LI Ning. Simultaneous determination of 10 spiked chemical drugs in antihypertensive herb preparations and health foods by microemulsion liquid chromatography[J]. Chinese Journal of Chromatography, ;2017, 35(2): 203-210. doi: 10.3724/SP.J.1123.2016.09019 shu

Simultaneous determination of 10 spiked chemical drugs in antihypertensive herb preparations and health foods by microemulsion liquid chromatography

LI Liangxing ^1,2, ,
LAI Caiyun ¹ ,
ZHENG Aini ¹ ,
WU Hongxing ¹ ,
SU Caoyin ¹ ,
GAO Chongkai ¹ ,
LI Ning ¹

1.
Guangdong Pharmaceutical University, Guangzhou 510006, China;
2.
China National Analytical Center(Guangzhou), Guangzhou 510070, China

Received Date: 6 September 2016

Fund Project: National Natural Science Foundation of China (No. 81173525).

A method was developed for simultaneous determination of 10 spiked chemical drugs in antihypertensive herb preparations and health foods by microemulsion liquid chromatography (MELC). The nature and mass fraction of microemulsion components (surfactant, co-surfactant, and oil phase), the pH of microemulsion, and the type of the stationary-phase were investigated. Central composite design-response surface methodology was used. The optimized conditions for the separation of the 10 spiked chemical drugs were as follows:an Agela Promosil C18(2) column (250 mm×4.6 mm, 5 μm) was used at 30℃, and the microemulsion mobile phase (pH 3.0) consisted of 5.6% (mass fraction) polyoxyethylene lauryl ether (Brij35), 0.17% (mass fraction) sodium dodecylsulfate (SDS), 5.1% (mass fraction) n-butanol, 0.46% (mass fraction) cyclohexane and water (pH 3.0). The method is efficient, sensitive and environment friendly.
- microemulsion liquid chromatography (MELC),
- antihypertensive,
- herb preparations,
- health foods,
- chemical drugs
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
10. [10]
11. [11]
12. [12]
13. [13]
14. [14]
15. [15]
16. [16]
17. [17]
18. [18]
19. [19]
20. [20]
21. [21]
22. [22]
23. [23]
24. [24]
25. [25]
26. [26]
27. [27]
1. [1]
  Peng Zhan . Practice and Reflection in Training Medicinal Chemistry Graduate Students. University Chemistry, 2024, 39(6): 112-121. doi: 10.3866/PKU.DXHX202402022
2. [2]
  Zhibei Qu , Changxin Wang , Lei Li , Jiaze Li , Jun Zhang . Organoid-on-a-Chip for Drug Screening and the Inherent Biochemistry Principles. University Chemistry, 2024, 39(7): 278-286. doi: 10.3866/PKU.DXHX202311039
3. [3]
  Hengwei Wei , Liqiu Zhao , Jiqiang Geng , Xuebo Xu , Yingpeng Ma , Yuhao Liu , Mingzhe Han , Huan Jiao , Lingling Wei . Research on Safety Management of Hazardous Chemicals and Talent Cultivation in Universities Driven by Production-Education Integration. University Chemistry, 2024, 39(10): 289-298. doi: 10.12461/PKU.DXHX202403022
4. [4]
  Ziheng Zhuang , Xiao Xu , Kin Shing Chan . Superdrugs for Superbugs. University Chemistry, 2024, 39(9): 128-133. doi: 10.3866/PKU.DXHX202309040
5. [5]
  Zijian Jiang , Yuang Liu , Yijian Zong , Yong Fan , Wanchun Zhu , Yupeng Guo . Preparation of Nano Zinc Oxide by Microemulsion Method and Study on Its Photocatalytic Activity. University Chemistry, 2024, 39(5): 266-273. doi: 10.3866/PKU.DXHX202311101
6. [6]
  Hongsheng Tang , Yonghe Zhang , Dexiang Wang , Xiaohui Ning , Tianlong Zhang , Yan Li , Hua Li . A Wonderful Journey through the Kingdom of Hazardous Chemicals. University Chemistry, 2024, 39(9): 196-202. doi: 10.12461/PKU.DXHX202403098
7. [7]
  Qin Li , Ziyao Jia , Ye Chen , Mingze Ma , Lin Li , Tao Huang . A Journey into the Enigmatic World of Pickering Emulsion: A Chemical Science Popularization Experiment. University Chemistry, 2024, 39(9): 311-318. doi: 10.3866/PKU.DXHX202306035
8. [8]
  Yu Wang , Shoulei Zhang , Tianming Lv , Yan Su , Xianyu Liu , Fuping Tian , Changgong Meng . Introduce a Comprehensive Inorganic Synthesis Experiment: Synthesis of Nano Zinc Oxide via Microemulsion Using Waste Soybean Oil. University Chemistry, 2024, 39(7): 316-321. doi: 10.3866/PKU.DXHX202311035
9. [9]
  Min Gu , Huiwen Xiong , Liling Liu , Jilie Kong , Xueen Fang . Rapid Quantitative Detection of Procalcitonin by Microfluidics: An Instrumental Analytical Chemistry Experiment. University Chemistry, 2024, 39(4): 87-93. doi: 10.3866/PKU.DXHX202310120
10. [10]
  Zhilian Liu , Wengui Wang , Hongxiao Yang , Yu Cui , Shoufeng Wang . Ideological and Political Education Design for the Synthesis of Irinotecan Drug Intermediate 7-Ethyl Camptothecin. University Chemistry, 2024, 39(2): 89-93. doi: 10.3866/PKU.DXHX202306012
11. [11]
  Zheqi Wang , Yawen Lin , Shunliu Deng , Huijun Zhang , Jinmei Zhou . Antiviral Strategies: A Brief Review of the Development History of Small Molecule Antiviral Drugs. University Chemistry, 2024, 39(9): 85-93. doi: 10.12461/PKU.DXHX202403108
12. [12]
  Yujia Luo , Yunpeng Qi , Huiping Xing , Yuhu Li . The Use of Viscosity Method for Predicting the Life Expectancy of Xuan Paper-based Heritage Objects. University Chemistry, 2024, 39(8): 290-294. doi: 10.3866/PKU.DXHX202401037
13. [13]
  Dongxia Zhang , Sijia Hao , Jiarui Wang , Jiwei Wang , Xiaogang Dong , Liang Jiao . Construction and Reflection on the Safety Management of Hazardous Chemicals in University Laboratories. University Chemistry, 2024, 39(10): 229-235. doi: 10.12461/PKU.DXHX202403078
14. [14]
  Bingliang Li , Yuying Han , Dianyang Li , Dandan Liu , Wenbin Shang . One-Step Synthesis of Benorilate Guided by Green Chemistry Principles and in vivo Dynamic Evaluation. University Chemistry, 2024, 39(6): 342-349. doi: 10.3866/PKU.DXHX202311070
15. [15]
  Zhuo Wang , Xue Bai , Kexin Zhang , Hongzhi Wang , Jiabao Dong , Yuan Gao , Bin Zhao . MOF模板法合成氮掺杂碳材料用于增强电化学钠离子储存和去除. Acta Physico-Chimica Sinica, 2025, 41(3): 2405002-. doi: 10.3866/PKU.WHXB202405002
16. [16]
  Xinxue Li . The Application of Reverse Thinking in Teaching of Boiling Point Elevation and Freezing Point Depression of Dilute Solutions in General Chemistry. University Chemistry, 2024, 39(11): 359-364. doi: 10.3866/PKU.DXHX202401075
17. [17]
  Haiyu Nie , Chenhui Zhang , Fengpei Du . Ideological and Political Design for the Preparation, Characterization and Particle Size Control Experiment of Nanoemulsion. University Chemistry, 2024, 39(2): 41-46. doi: 10.3866/PKU.DXHX202306055
18. [18]
  Gaofeng Zeng , Shuyu Liu , Manle Jiang , Yu Wang , Ping Xu , Lei Wang . Micro/Nanorobots for Pollution Detection and Toxic Removal. University Chemistry, 2024, 39(9): 229-234. doi: 10.12461/PKU.DXHX202311055
19. [19]
  Juan Yang . Construction of General Chemistry Course in the Chemistry “101 Plan”. University Chemistry, 2024, 39(10): 8-13. doi: 10.12461/PKU.DXHX202408026
20. [20]
  Hongyan Chen , Yajun Hou , Shui Hu , Zhuoxun Wei , Fang Zhu , Chengyong Su . Construction of Synthetic Chemistry Experiment of the Chemistry “101 Plan”. University Chemistry, 2024, 39(10): 58-63. doi: 10.12461/PKU.DXHX202409109

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(198)
HTML views(27)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return