Citation: GAO Wen, SONG Huipeng, YANG Hua, LI Ping. Application progress of on-line two-dimensional liquid-chromatography in the analysis of traditional Chinese medicines[J]. Chinese Journal of Chromatography, ;2017, 35(1): 121-128. doi: 10.3724/SP.J.1123.2016.08045 shu

Application progress of on-line two-dimensional liquid-chromatography in the analysis of traditional Chinese medicines

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China

Received Date: 31 August 2016

Fund Project: National Natural Science Foundation of China (No. 81503241)

Traditional Chinese medicine (TCM) is a complex system, containing hundreds of components. The chemical profiling of TCMs is an important task and still facing great challenges. In recent years, the on-line two-dimensional liquid-chromatography (2D-LC) methods, emerging and powerful separation techniques, offer new possibilities for the global analysis of complex TCM samples. Recent advances of 2D-LC, including heart-cutting two-dimensional liquid-chromatography (heart-cutting LC-LC) and comprehensive two-dimensional liquid-chromatography (comprehensive LC×LC), applied to TCMs analysis are reviewed. Design and application of 2D-LC combined with turbulent flow chromatography (TFC) or cell membrane chromatography (CMC) applied for TCM bioactive components screening are described.
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