Citation: WANG Keyun, YE Mingliang, ZOU Hanfa. Recent advances in proteomic analysis of protein methylation[J]. Chinese Journal of Chromatography, ;2016, 34(12): 1161-1167. doi: 10.3724/SP.J.1123.2016.08023 shu

Recent advances in proteomic analysis of protein methylation

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, National Chromatographic Research and Analysis Center, Dalian 116023, China

Received Date: 22 August 2016

Fund Project: National Science Fund of China for Distinguished Young Scholars (No. 21525524)

Protein methylation is one of the most important post-modificational modifications. Compared with the widely studied phoshporylation, glycosylation and ubiquitylation, the methylome analysis is still at nascent stage. In recent years, more and more attentions have been drawn to the researches of protein methylation for its important role in the epigenetic regulation and considerable advances have been achieved. Of them, the MS based proteomic approaches play a key role by achieving the high-throughput analysis of protein methylation. In this review, advances in proteomic analysis of protein methylation are summarized in three aspects:selective enrichment, identification confidence controlling and quantitative analysis.
- protein methylation,
- selective enrichment,
- confidence controlling,
- quantitative proteomics,
- review
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