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Citation: LI Yang, FENG Hua, JIANG Denggao. Preparation and application of covalently bonded cellulose acetylsalicylate chiral stationary phases[J]. Chinese Journal of Chromatography, ;2016, 34(8): 739-744. doi: 10.3724/SP.J.1123.2016.04026 shu

Preparation and application of covalently bonded cellulose acetylsalicylate chiral stationary phases

LI Yang ^1,, ,
FENG Hua ² ,
JIANG Denggao ³

1.
1. Henan Institute for Food and Drug Control, Zhengzhou 450003, China;
2.
2. Women and Infants Hospital of Zhengzhou, Zhengzhou 450003, China;
3.
3. School of Chemical Engineering and Energy, Zhengzhou University, Zhengzhou 450001, China

Corresponding author: LI Yang,
Received Date: 15 April 2016

The chemical bonded cellulose acetylsalicylate chiral stationary phase (CSP1) was obtained by fixing cellulose derivative on silica gel with beta-(3, 4-epoxycyclohexyl) ethyl trimethoxy silane as space arm. The resolution mechanism and feasibility of CSP1 were studied by comparing CSP1 with coated chiral stationary phase prepared by cellulose acetylsalicylate. The role of cyclohexyl group in the space arm was also verified by comparing CSP1 with CSP2 which had no cyclohexyl group in the space arm. Based on the chromatographic results, the immobilized chiral stationary phase exhibited better chiral resolving abilities than coated stationary phase for imidazoles. It is due to, on the one hand, more types of mobile phases used, on the other hand, the modified cellulose by cyclohexyl group.
- cellulose acetylsalicylate,
- chiral stationary phase,
- space arm,
- bond
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