Citation: YONG Tian, WU Fan, XIAO Hongbin, WAN Boshun. Preparation of xylitol and maltitol modified silica as novel stationary phases for hydrophilic interaction liquid chromatography and evaluation of their separation performance[J]. Chinese Journal of Chromatography, ;2015, 33(9): 910-916. doi: 10.3724/SP.J.1123.2015.04024 shu

Preparation of xylitol and maltitol modified silica as novel stationary phases for hydrophilic interaction liquid chromatography and evaluation of their separation performance

YONG Tian ¹ ,
WU Fan ¹ ,
XIAO Hongbin ^1,2,, ,
WAN Boshun ^1,,

1.
1. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;

Corresponding author: XIAO Hongbin, WAN Boshun,
Received Date: 15 April 2015

Fund Project: 国家重大新药创制专项课题(2014XZ09304-307) (2014XZ09304-307)国家"863计划"课题(2014AA022201-02). (2014AA022201-02)

New types of stationary phases for hydrophilic interaction liquid chromatography (HILIC) with unique selectivity are very important for the separation of various polar and hydrophilic analytes. Two novel HILIC stationary phases based on sugar alcohol modified silica were synthesized by a simple two-step reaction in which xylitol and maltitol were bonded onto the surface of silica particles via the addition reaction between-NCO and-OH. The effect of acetonitrile content on the retention indicated that the two stationary phases were of typical HILIC character and exhibited strong retention for polar and hydrophilic analytes. They succeeded in the separation of a wide range of polar and hydrophilic analytes including water soluble vitamins, salicylic acid and its analogues, nucleic acid bases and nucleosides, and icariin and its analogues with unique selectivity. Especially, the maltitol stationary phase showed unique selectivity on glycosyl group, compared to xylitol stationary phase. Furthermore, the effects of buffer pH as well as salt concentration on the retention indicated that electrostatic interaction played an important role in the separation mechanism of the two stationary phases. For sure, the efficient stationary phases are of great potential applications in HILIC.
- hydrophilic interaction liquid chromatography (HILIC),
- stationary phases,
- sugar alcohol,
- glycosyl group,
- selectivity
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