Citation: ZHANG Hong, YANG Fengmin, SHEN Gang, YANG Yueyang, TANG Yalin. Comparison of the release behaviors of di(2-ethylhexyl) phthalate and tri(2-ethylhexyl) trimellitate from the polyvinyl-chloride infusion set into pharmaceutical solutions[J]. Chinese Journal of Chromatography, ;2015, 33(5): 522-529. doi: 10.3724/SP.J.1123.2014.12029 shu

Comparison of the release behaviors of di(2-ethylhexyl) phthalate and tri(2-ethylhexyl) trimellitate from the polyvinyl-chloride infusion set into pharmaceutical solutions

1.
1. State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;

Corresponding author: TANG Yalin,
Received Date: 22 December 2014

Fund Project: National Natural Science Foundation of China (Grant No. 21302188). (Grant No. 21302188)

Polyvinyl-chloride (PVC) with plasticizers of di(2-ethylhexyl) phthalate (DEHP) and tris(2-ethylhexyl) trimellitate (TOTM) is widely used in medical and paramedical appliances. However, such plasticizers can leach from PVC products into contact solutions. The aim of this study is to investigate the release behaviors of DEHP and TOTM from the PVC intravenous infusion set into various pharmaceutical solutions under the simulated clinical conditions, such as the lipophilic substances (paclitaxel), parenteral nutrition (fat emulsion injection), acid and alkali pharmaceutical solution (levofloxacin hydrochloride injection, pH 3.0-5.0 and furosemide, pH 8.0-9.0). A simple and rapid high-performance liquid chromatographic method with UV detection (HPLC-UV) for the determination of DEHP or TOTM released from PVC medical devices into the above intravenous preparations was developed. The cumulative amounts of DEHP or TOTM released in 24 h were in the same following order: paclitaxel>fat emulsion injection>levofloxacin hydrochloride> furosemide solution. From a comparison of the cumulative amounts of released DEHP and TOTM from the above solutions, we found that the cumulative amount of TOTM is far less than that of DEHP, under the same conditions. The cumulative amount of the DEHP released in 24 h in the paclitaxel solution was 21.14 mg, while under the same conditions, the cumulative amount of TOTM was only 0.078 mg. The cumulative amount of DEHP is assumed to be about 270 times that of the released TOTM. Thus TOTM could be a superior alternative to DEHP for use in medical devices because of its potential lower leachability.
1. [1]
  [1] Bernard L, Cueff R, Bourdeaux D, et al. Anal Bioanal Chem, 2015, 407: 1651
2. [2]
  [2] Wu W, Hu J, Wang J, et al. Sci Total Environ, 2015, 508: 445
3. [3]
  [3] Kambia K, Dine T, Azar R, et al. Int J Pharm, 2001, 229: 139
4. [4]
  [4] Kambia K, Dine T, Gressier B, et al. J Chromatogr B, 2001, 755: 297
5. [5]
  [5] Xu D M, Deng X J, Fang E H, et al. J Chromatogr A, 2014, 1324: 49
6. [6]
  [6] Wang M L, Kou L J, Zhang Y Q, et al. Chinese Journal of Chromatography, 2007, 25(4): 577
7. [7]
  [7] Lai Y, Huang Z P, Ge X X, et al. Chinese Journal of Chromatography, 2012, 30(7): 647
8. [8]
  [8] Liu P Y, Gao L, Shen J, et al. Chinese Journal of Chromatography, 2010, 28(5): 517
9. [9]
  [9] Xu X H, Yang Y L, Wang R, et al. Chemosphere, 2015, 124: 22
10. [10]
  [10] Heudorf U, Mersch-Sundermann V, Angerer J. Int J Hyg Environ Health, 2007, 210: 623
11. [11]
  [11] Lin Y, Min L, Huang Q S, et al. Environ Toxicol, 2015, 30(2): 197
12. [12]
  [12] European Union. Directive 2007/47/EC of the European Parliament and of the Council of 5 September 2007 Amending Council Directive 90/385/EEC on the Approximation of the Laws of the Member States Relating to Active Implantable Medical Devices, Council Directive 93/42/EEC Concerning Medical Devices and Directive 98/8/EC Concerning the Placing of Biocidal Products on the Market. (2007-09-05). http://eur-lex.europa.eu/legal-content/en/ALL/?uri=CELEX: 32007L0047
13. [13]
  [13] Bernard L, Decaudin B, Lecoeur M, et al. Talanta, 2014, 129: 39
14. [14]
  [14] Wang H H, Chen K, Lin C, et al. Vox Sanguinis, 2013, 105: 143
15. [15]
  [15] Chiera A O, Rimorini L, Krause L E, et al. Vox Sanguinis, 2012, 103: 270
16. [16]
  [16] Ito R, Miura N, Iguchi H, et al. Int J Pharm, 2008, 360: 91
17. [17]
  [17] Loff S, Kabs F, Witt K, et al. J Pediatr Surg, 2000, 35: 1775
18. [18]
  [18] Takehisa H, Naoko E, Masahiko S, et al. Int J Pharm, 2005, 297: 30
19. [19]
  [19] Welle F, Wolz G, Franz R. Forschung und Entwicklung, 2005, 3: 17
20. [20]
  [20] Genay S, Luciani C, Decaudin B, et al. Int J Pharm, 2011, 412: 47
1. [1]
  Shiyi Chen , Jialong Fu , Jianping Qiu , Guoju Chang , Shiyou Hao . Waste medical mask-derived carbon quantum dots enhance the photocatalytic degradation of polyethylene terephthalate (PET) over BiOBr/g-C₃N₄ S-scheme heterojunction. Acta Physico-Chimica Sinica, 2026, 42(1): 100135-0. doi: 10.1016/j.actphy.2025.100135
2. [2]
  Yu Peng , Jiawei Chen , Yue Yin , Yongjie Cao , Mochou Liao , Congxiao Wang , Xiaoli Dong , Yongyao Xia . Tailored cathode electrolyte interphase via ethylene carbonate-free electrolytes enabling stable and wide-temperature operation of high-voltage LiCoO₂. Acta Physico-Chimica Sinica, 2025, 41(8): 100087-0. doi: 10.1016/j.actphy.2025.100087
3. [3]
  Yanhui Zhong , Ran Wang , Zian Lin . Analysis of Halogenated Quinone Compounds in Environmental Water by Dispersive Solid-Phase Extraction with Liquid Chromatography-Triple Quadrupole Mass Spectrometry. University Chemistry, 2024, 39(11): 296-303. doi: 10.12461/PKU.DXHX202402017
4. [4]
  Jinghua Wang , Yanxin Yu , Yanbiao Ren , Yesheng Wang . Integration of Science and Education: Investigation of Tributyl Citrate Synthesis under the Promotion of Hydrate Molten Salts for Research and Innovation Training. University Chemistry, 2024, 39(11): 232-240. doi: 10.3866/PKU.DXHX202402057
5. [5]
  Ling Liu , Haibin Wang , Genrong Qiang . Curriculum Ideological and Political Design for the Comprehensive Preparation Experiment of Ethyl Benzoate Synthesized from Benzyl Alcohol. University Chemistry, 2024, 39(2): 94-98. doi: 10.3866/PKU.DXHX202304080
6. [6]
  Yajin Li , Huimin Liu , Lan Ma , Jiaxiong Liu , Dehua He . Photothermal Synthesis of Glycerol Carbonate via Glycerol Carbonylation with CO₂ over Au/Co₃O₄-ZnO Catalyst. Acta Physico-Chimica Sinica, 2024, 40(9): 2308005-0. doi: 10.3866/PKU.WHXB202308005
7. [7]
  Jianding LI , Junyang FENG , Huimin REN , Gang LI . Proton conductive properties of a Hf(Ⅳ)-based metal-organic framework built by 2,5-dibromophenyl-4,6-dicarboxylic acid. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1094-1100. doi: 10.11862/CJIC.20240464
8. [8]
  Yanhui Guo , Li Wei , Zhonglin Wen , Chaorong Qi , Huanfeng Jiang . Recent Progress on Conversion of Carbon Dioxide into Carbamates. Acta Physico-Chimica Sinica, 2024, 40(4): 2307004-0. doi: 10.3866/PKU.WHXB202307004
9. [9]
  Wanmin Cheng , Juan Du , Peiwen Liu , Yiyun Jiang , Hong Jiang . Photoinitiated Grignard Reagent Synthesis and Experimental Improvement in Triphenylmethanol Preparation. University Chemistry, 2024, 39(5): 238-242. doi: 10.3866/PKU.DXHX202311066
10. [10]
  Xiyuan Zhang , Rui Dong , Yang Yang , Jiapeng Ding , Zhiwei Miao . Palladium-Catalyzed Tandem Cyclization of 4-Vinylbenzoxazinone and Indene-2-carbaldehyde: A Comprehensive Organic Chemistry Experiment. University Chemistry, 2025, 40(9): 361-367. doi: 10.12461/PKU.DXHX202410062
11. [11]
  Zhenhuan Wang , Weifei Wei , Ruijie Ma , Dou Luo , Zhanxiang Chen , Jun Zhang , Liyang Yu , Gang Li , Zhenghui Luo . Core cyanation of benzo[a]phenazine acceptor enables 19.04% binary organic solar cells with green solvent compatibility. Acta Physico-Chimica Sinica, 2026, 42(2): 100182-0. doi: 10.1016/j.actphy.2025.100182
12. [12]
  Liyang ZHANG , Dongdong YANG , Ning LI , Yuanyu YANG , Qi MA . Crystal structures, luminescent properties and Hirshfeld surface analyses of three cadmium(Ⅱ) complexes based on 2-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)benzoate. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1943-1952. doi: 10.11862/CJIC.20240079
13. [13]
  Zhen FAN , Jiayan WANG , Wenhao ZHU , Xiuchun ZHANG , Yang WANG , Hao LI , Zeyuan WANG , Songzhi ZHENG , Weihai SUN . Fabrication of CsPbBr₃ perovskite solar cells using buried polyvinylidene fluorideinterface modification method. Chinese Journal of Inorganic Chemistry, 2025, 41(12): 2464-2478. doi: 10.11862/CJIC.20250191
14. [14]
  Lifang HE , Wenjie TANG , Yaoze LUO , Mingsheng LIANG , Jianxin TANG , Yuxuan WU , Fuxing ZHANG , Xiaoming ZHU . Synthesis, structure, and anticancer activity of two dialkyltin complexes constructed based on 2, 2′-bipyridin-6, 6′-dicarboxylic acid. Chinese Journal of Inorganic Chemistry, 2025, 41(8): 1601-1609. doi: 10.11862/CJIC.20250012
15. [15]
  Yifan Xie , Liyun Yao , Ruolin Yang , Yuxing Cai , Yujie Jin , Ning Li . Exploration and Practice of Online and Offline Hybrid Teaching Mode in High-Performance Liquid Chromatography Experiment. University Chemistry, 2025, 40(11): 100-107. doi: 10.12461/PKU.DXHX202412133
16. [16]
  Runjie Li , Hang Liu , Xisheng Wang , Wanqun Zhang , Wanqun Hu , Kaiping Yang , Qiang Zhou , Si Liu , Pingping Zhu , Wei Shao . 氨基酸的衍生及手性气相色谱分离创新实验. University Chemistry, 2025, 40(6): 286-295. doi: 10.12461/PKU.DXHX202407059
17. [17]
  Qianping Li , Hua Guan , Changfeng Wan , Yonghai Song , Jianwen Jiang . 大学有机化学复习课项目式教学——以“液晶化合物4-正戊基苯甲酸-4′-正戊基苯酯的合成路线设计与产品制备”为例. University Chemistry, 2025, 40(8): 100-116. doi: 10.12461/PKU.DXHX202410070
18. [18]
  Jian Jin , Jing Cheng , Xueping Yang . Integration Practice of Organic Chemistry Experiment and Safety Education: Taking the Synthesis of Triphenylmethanol as an Example. University Chemistry, 2024, 39(3): 345-350. doi: 10.3866/PKU.DXHX202309010
19. [19]
  Feng Han , Fuxian Wan , Ying Li , Congcong Zhang , Yuanhong Zhang , Chengxia Miao . Comprehensive Organic Chemistry Experiment: Phosphotungstic Acid-Catalyzed Direct Conversion of Triphenylmethanol for the Synthesis of Oxime Ethers. University Chemistry, 2025, 40(3): 342-348. doi: 10.12461/PKU.DXHX202405181
20. [20]
  Lirui Shen , Kun Liu , Ying Yang , Dongwan Li , Wengui Chang . Synthesis and Application of Decanedioic Acid-N-Hydroxysuccinimide Ester: Exploration of Teaching Reform in Comprehensive Applied Chemistry Experiment. University Chemistry, 2024, 39(8): 212-220. doi: 10.3866/PKU.DXHX202312035

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(374)
HTML views(33)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142