Citation: GOU Xinlei, GAO Xia, HU Guanghui, LIU Weili. Simultaneous determination of nine antidepressants in traditional Chinese medicines and health food by ultra performance liquid chromatography with tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2014, 32(8): 822-826. doi: 10.3724/SP.J.1123.2014.03032 shu

Simultaneous determination of nine antidepressants in traditional Chinese medicines and health food by ultra performance liquid chromatography with tandem mass spectrometry

GOU Xinlei ¹ ,
GAO Xia ^1,2,, ,
HU Guanghui ¹ ,
LIU Weili ^1,2

1.
1. Beijing Centre for Physical and Chemical Analysis, Beijing 100089, China;

Corresponding author: GAO Xia,
Received Date: 21 March 2014
Available Online: 4 April 2014
Fund Project: 北京市自然科学基金项目(2122018) (2122018)北京市科学技术研究院创新团队计划项目(IG200801N/C2). (IG200801N/C2)

A sensitive method was developed for the simultaneous determination of nine antidepressants in traditional Chinese medicines and health food by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) based on the sonication-assisted extraction. The separation was performed on a Waters ACQUITY UPLC BEH C₁₈ column (100 mm×2.1 mm, 1.7 μm) by using 0.1% (v/v) formic acid aqueous solution and acetonitrile as the mobile phases with gradient elution at a flow rate of 0.2 mL/min. The electrospray ionization (ESI) source in positive ion mode was used for the analysis of the nine antidepressants in the multiple reaction monitoring (MRM) mode. The standard curves for the nine antidepressants were obtained with good correlation coefficients (R²>0.998) in the concentration range of 0.04-20 μg/L. The limits of detection for the nine antidepressants were in the range of 0.0068-0.034 μg/L. The average recoveries at three spiked levels (0.5, 1, 5 μg/L) were 77.7%-100.8% with the relative standard deviation of 0.9%-9.1%. The method is accurate, simple, rapid and feasible for the simultaneous determination of the antidepressants in traditional Chinese medicines and health food.
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