Citation: ZHANG Haijing, LIN Shaobin. Determination of eight bisphenol diglycidyl ethers in water by solid phase extraction-high performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2014, 32(7): 730-734. doi: 10.3724/SP.J.1123.2014.02026 shu

Determination of eight bisphenol diglycidyl ethers in water by solid phase extraction-high performance liquid chromatography-tandem mass spectrometry

ZHANG Haijing ,
LIN Shaobin ^,

1.
Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China

Corresponding author: LIN Shaobin,
Received Date: 27 February 2014
Available Online: 15 April 2014
Fund Project: 卫生行业科研专项项目(201002001). (201002001)

A solid phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry (SPE-HPLC-MS/MS) method was developed for the determination of eight bisphenol diglycidyl ethers, including bisphenol A diglycidyl ether (BADGE), bisphenol A (3-chloro-2-hydroxypropyl) glycidyl ether(BADGE·5HCl), bisphenol A bis(3-chloro-2-hydroxypropyl) ether(BADGE·52HCl), bisphenol A (2,3-dihydroxypropyl) glycidyl ether(BADGE·5H₂O), bisphenol A bis(2,3-dihydroxypropyl) ether(BADGE·52H₂O), bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether(BADGE·5HCl·5H₂O), bisphenol F diglycidyl ether(BFDGE) and bisphenol F bis(3-chloro-2-hydroxypropyl) ether(BFDGE·52HCl) in water. A total of ten samples were collected from the leaching of the coatings for drinking water supply system. Then, 200 mL exposure water was preconcentrated on C₁₈ solid-phase extraction cartridge. The eight compounds were analyzed by liquid chromatography-tandem mass spectrometry method on a C₁₈ column by the gradient elution with methanol, water and 5 mmol/L ammonium acetate as mobile phases in the multiple reaction monitoring (MRM) scan mode. The external matrix standard solutions were used for the quantitative determination and the calibration curves of the eight compounds showed good linearity in the range of 0.007-5.00 μg/L with the correlation coefficients more than 0.9990. The limits of quantification (LOQs) of the method were 7-91 ng/L. The spiked recoveries ranged from 79.1% to 101% with the relative standard deviations of 4.0%-12%. The method is sensitive and accurate, and is applicable to the determination of bisphenol diglycidyl ethers in water.
- high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS),
- bisphenol diglycidyl ether,
- water,
- exposure water,
- coatings
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沈阳化工大学材料科学与工程学院沈阳 110142