Citation: GAO Yangyang, ZHANG Zhaohui, LIU Xin, LU Xiaoyu, YAN Hua, HE Yue, YANG Dajin, YUN Huan. Determination of sulfonamide potentiators in animal origin foods by ultra performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2014, 32(5): 524-528. doi: 10.3724/SP.J.1123.2014.01008 shu

Determination of sulfonamide potentiators in animal origin foods by ultra performance liquid chromatography-tandem mass spectrometry

GAO Yangyang ¹ ,
ZHANG Zhaohui ¹ ,
LIU Xin ¹ ,
LU Xiaoyu ¹ ,
YAN Hua ¹ ,
HE Yue ¹ ,
YANG Dajin ² ,
YUN Huan ^1,,

1.
1. Technology Center of Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 100026, China;

Corresponding author: YUN Huan,
Received Date: 6 January 2014
Available Online: 18 March 2014
Fund Project: 科技部质检公益行业科研专项(201210029) (201210029)国家高技术研究发展计划(“863”计划)项目(2012AA101603). (“863”计划)项目(2012AA101603)

A method for the determination of sulfonamide potentiators, trimethoprim (TMP), diaveridine (DVD) and ormetoprin (OMP), in different animal origin food matrices (including chicken muscle, fish muscle, chicken liver, egg and milk) has been developed by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The sample was extracted by formic acid-acetonitrile (1:9, v/v), cleaned-up by hexane, separated on an Acquity UPLC BEH C18 column (50 mm×2.1 mm, 1.7 μm) with gradient elution. The determination was carried out with electrospray ion source under the positive mode and multiple reaction monitoring (MRM) mode. The extraction recoveries of three extraction solvents were observed. The purification condition and concentration condition were optimized. In addition, the mobile phase, column temperature and solid phase extraction column were studied. The calibration curves showed a good linearity in the range of 1.25-30.0 μg/L, and the correlation coefficients (r) were higher than 0.99. The limits of quantification (LOQ, S/N=10) of the three potentiators were 5.0 μg/kg. At the spiked levels of 5.0, 10.0 and 20.0 μg/kg, the recoveries of the three potentiators were ranged from 61.2% to 108.5%, and the relative standard deviations (RSD, n=6) ranged from 1.1% to 9.8%. The results indicate that the method is simple, rapid, sensitive and suitable for the qualitative and quantitative analysis of the three potentiators in multiple matrices.
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